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%Begin Testosterone Real-World Data Search Skip to content Menu Menu follow us Store Articles Community Loyal-T Club Loyal-T Points Rewards Subscribe to Save Search Search The World s Trusted Source & Community for Elite Fitness Alpha LifePharmaSex & Hormones Testosterone Real-World Data by Tim Ziegenfuss, PhD June 14, 2002June 8, 2021 Tags Living Better, Pharma, TRT If you've so much as picked up a newspaper in the last couple of weeks, or even a Time, Newsweek, Sports Illustrated, People, or friggin' Weekly Reader, you've no doubt been force fed yet another article about the horrors of steroids. Yep, steroids are no doubt what the terrorists are planning on dropping into our drinking water, thus creating a horrible epidemic of exploding livers and diminutive testicles that drop out of our pants like tiny popcorn kernels left over from last night's viewing of "The Secret Ya-Ya Sisterhood." Thankfully, there's some real world research going on about steroid hormones (not much, mind you, but some). Recently, researachers Shalender Bhasin, Linda Woodhouse, Richard Casaburi et al.
Andrew Wilson Member
access_time 4 minutes ago
%Begin Testosterone Real-World Data Search Skip to content Menu Menu follow us Store Articles Community Loyal-T Club Loyal-T Points Rewards Subscribe to Save Search Search The World s Trusted Source & Community for Elite Fitness Alpha LifePharmaSex & Hormones Testosterone Real-World Data by Tim Ziegenfuss, PhD June 14, 2002June 8, 2021 Tags Living Better, Pharma, TRT If you've so much as picked up a newspaper in the last couple of weeks, or even a Time, Newsweek, Sports Illustrated, People, or friggin' Weekly Reader, you've no doubt been force fed yet another article about the horrors of steroids. Yep, steroids are no doubt what the terrorists are planning on dropping into our drinking water, thus creating a horrible epidemic of exploding livers and diminutive testicles that drop out of our pants like tiny popcorn kernels left over from last night's viewing of "The Secret Ya-Ya Sisterhood." Thankfully, there's some real world research going on about steroid hormones (not much, mind you, but some). Recently, researachers Shalender Bhasin, Linda Woodhouse, Richard Casaburi et al.
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Ethan Thomas 2 minutes ago
(of Charles R. Drew University of Medicine and Science, Harbor-University of California Los Angeles ...
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Joseph Kim 3 minutes ago
Instead, they focused on "normal" men and their responses to graded doses of this macho ho...
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(of Charles R. Drew University of Medicine and Science, Harbor-University of California Los Angeles Medical Center, Washington University School of Medicine) did a pretty tidy little study on our beloved Testosterone (in this case, the hormone, not the magazine). The title of the study is, "Testosterone dose-response relationships in healthy young men." As you might guess, they didn't study any 300 lb ripped-to-the-bone bodybuilders claiming to be drug free (yeah right).
Henry Schmidt Member
access_time 8 minutes ago
(of Charles R. Drew University of Medicine and Science, Harbor-University of California Los Angeles Medical Center, Washington University School of Medicine) did a pretty tidy little study on our beloved Testosterone (in this case, the hormone, not the magazine). The title of the study is, "Testosterone dose-response relationships in healthy young men." As you might guess, they didn't study any 300 lb ripped-to-the-bone bodybuilders claiming to be drug free (yeah right).
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Instead, they focused on "normal" men and their responses to graded doses of this macho hormone. Subjects The subjects in this study consisted of 61 healthy men between the ages of 18-35 years. All had prior weightlifting experience, normal Tstosterone levels, and hadn't used any anabolic agents in the preceding year.
Sophia Chen Member
access_time 12 minutes ago
Instead, they focused on "normal" men and their responses to graded doses of this macho hormone. Subjects The subjects in this study consisted of 61 healthy men between the ages of 18-35 years. All had prior weightlifting experience, normal Tstosterone levels, and hadn't used any anabolic agents in the preceding year.
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Scarlett Brown 1 minutes ago
All received monthly injections of a long-acting GnRH agonist to suppress endogenous Testosterone pr...
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Dylan Patel 8 minutes ago
Remember, these are the test subject's values at the time the study began. Group Dose Body weig...
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All received monthly injections of a long-acting GnRH agonist to suppress endogenous Testosterone production (now that's gotta hurt). Depending on which group they were randomized to, subjects received one of five different weekly doses of Testosterone enanthate for five months (note: there were no significant differences between groups for any variable at the start of the study).
James Smith Moderator
access_time 4 minutes ago
All received monthly injections of a long-acting GnRH agonist to suppress endogenous Testosterone production (now that's gotta hurt). Depending on which group they were randomized to, subjects received one of five different weekly doses of Testosterone enanthate for five months (note: there were no significant differences between groups for any variable at the start of the study).
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Dylan Patel 4 minutes ago
Remember, these are the test subject's values at the time the study began. Group Dose Body weig...
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Remember, these are the test subject's values at the time the study began. Group Dose Body weight (kg) Age (yr) FFM (kg) Basal T (ng/dL) Leg press strength (kg) 1 25 mg 68.0 28 59.1 593 355.5 2 50 mg 77.0 29 65.1 566 407.8 3 125 mg 78.9 28 66.0 553 419.2 4 300 mg 78.4 24 67.3 654 439.8 5 600 mg 74.8 25 64.2 632 431.6 Diet Control Two weeks before their first intramuscular injection, subjects began following a standardized diet consisting of 36 kcal/kg body weight per day (16.4 kcals/lb) and 1.2 grams protein per kilogram body weight per day (0.55 grams/lb).
Charlotte Lee Member
access_time 25 minutes ago
Remember, these are the test subject's values at the time the study began. Group Dose Body weight (kg) Age (yr) FFM (kg) Basal T (ng/dL) Leg press strength (kg) 1 25 mg 68.0 28 59.1 593 355.5 2 50 mg 77.0 29 65.1 566 407.8 3 125 mg 78.9 28 66.0 553 419.2 4 300 mg 78.4 24 67.3 654 439.8 5 600 mg 74.8 25 64.2 632 431.6 Diet Control Two weeks before their first intramuscular injection, subjects began following a standardized diet consisting of 36 kcal/kg body weight per day (16.4 kcals/lb) and 1.2 grams protein per kilogram body weight per day (0.55 grams/lb).
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To put these values in perspective, a 176-pound male would have to ingest 2880 kcals/day and 96 grams of protein/day. To make sure subjects didn't change their dietary habits during the study, they were asked to complete 3-day food records and 24-hr food recalls every four weeks. Activity Control Here's the only part of the study that surprised me, at least initially – subjects were asked NOT to perform any type of strength training or endurance exercise during the entire study.
William Brown Member
access_time 12 minutes ago
To put these values in perspective, a 176-pound male would have to ingest 2880 kcals/day and 96 grams of protein/day. To make sure subjects didn't change their dietary habits during the study, they were asked to complete 3-day food records and 24-hr food recalls every four weeks. Activity Control Here's the only part of the study that surprised me, at least initially – subjects were asked NOT to perform any type of strength training or endurance exercise during the entire study.
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Hannah Kim 7 minutes ago
This was done to avoid the potentially confounding influence that intense physical activity might ha...
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Hannah Kim 3 minutes ago
Yet another clear example of how time and monetary constraints influence research design. Outcome (d...
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This was done to avoid the potentially confounding influence that intense physical activity might have on the dependent variables. The more I thought about it, teasing out the effects that exercise might have on responses to Testosterone would have required an additional five groups (of men that did strength train). And as anyone who's done a research study will tell you, getting a sample size of 61 men is hard enough, but 120 men for a 20-week study?
Audrey Mueller Member
access_time 14 minutes ago
This was done to avoid the potentially confounding influence that intense physical activity might have on the dependent variables. The more I thought about it, teasing out the effects that exercise might have on responses to Testosterone would have required an additional five groups (of men that did strength train). And as anyone who's done a research study will tell you, getting a sample size of 61 men is hard enough, but 120 men for a 20-week study?
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Audrey Mueller 7 minutes ago
Yet another clear example of how time and monetary constraints influence research design. Outcome (d...
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Ethan Thomas 4 minutes ago
incorrect analyses of the data (can anyone say repeated T-tests and type-II error?). Luckily, these ...
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Yet another clear example of how time and monetary constraints influence research design. Outcome (dependent) Variables To underscore the comprehensive nature of this study, take a look at this list of outcome variables: • Fat-free mass (via underwater weighing and DEXA) • Fat mass (via underwater weighing and DEXA) • Thigh muscle volume (via MRI) • Quadriceps muscle volume (via MRI) • Total body water (via deuterium dilution) • Leg press strength (via 1-rep max) • Sexual function and desire (via daily logs) • Spatial cognition (via checkerboard test) • Mood (via Hamilton depression and Young manic scales) • Blood counts and clinical chemistries (too many analytes to list) • Prostate specific antigen (PSA) • Total cholesterol and various subfractions • Total and free Tstosterone • Luteinizing hormone (LH) • Sex hormone binding globulin (SHBH) • Insulin-like growth factor 1 (IGF-1) Statistical Gymnastics (oops, I mean analyses) This is where some very good studies sometimes go sour...
Ella Rodriguez Member
access_time 40 minutes ago
Yet another clear example of how time and monetary constraints influence research design. Outcome (dependent) Variables To underscore the comprehensive nature of this study, take a look at this list of outcome variables: • Fat-free mass (via underwater weighing and DEXA) • Fat mass (via underwater weighing and DEXA) • Thigh muscle volume (via MRI) • Quadriceps muscle volume (via MRI) • Total body water (via deuterium dilution) • Leg press strength (via 1-rep max) • Sexual function and desire (via daily logs) • Spatial cognition (via checkerboard test) • Mood (via Hamilton depression and Young manic scales) • Blood counts and clinical chemistries (too many analytes to list) • Prostate specific antigen (PSA) • Total cholesterol and various subfractions • Total and free Tstosterone • Luteinizing hormone (LH) • Sex hormone binding globulin (SHBH) • Insulin-like growth factor 1 (IGF-1) Statistical Gymnastics (oops, I mean analyses) This is where some very good studies sometimes go sour...
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Natalie Lopez 25 minutes ago
incorrect analyses of the data (can anyone say repeated T-tests and type-II error?). Luckily, these ...
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Christopher Lee 10 minutes ago
They even examined all variables for their distribution characteristics and log-transformed those va...
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incorrect analyses of the data (can anyone say repeated T-tests and type-II error?). Luckily, these researchers did their homework and used ANOVA to compare the changes from baseline among the five groups.
Ethan Thomas Member
access_time 36 minutes ago
incorrect analyses of the data (can anyone say repeated T-tests and type-II error?). Luckily, these researchers did their homework and used ANOVA to compare the changes from baseline among the five groups.
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Zoe Mueller 12 minutes ago
They even examined all variables for their distribution characteristics and log-transformed those va...
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They even examined all variables for their distribution characteristics and log-transformed those variables that didn't meet the assumptions of a normal distribution prior to analysis. Results Okay, here's what you've been waiting for. Let's start with hormone changes.
Charlotte Lee Member
access_time 30 minutes ago
They even examined all variables for their distribution characteristics and log-transformed those variables that didn't meet the assumptions of a normal distribution prior to analysis. Results Okay, here's what you've been waiting for. Let's start with hormone changes.
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Remember, weekly shots of GnRH assured that each subject's endogenous Testosterone production was at a minimum. Not surprisingly, 25 and 50 mg of Testosterone per week didn't "replace" what the GnRH had shut down.
Elijah Patel Member
access_time 44 minutes ago
Remember, weekly shots of GnRH assured that each subject's endogenous Testosterone production was at a minimum. Not surprisingly, 25 and 50 mg of Testosterone per week didn't "replace" what the GnRH had shut down.
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Noah Davis 24 minutes ago
125 mg/week seemed to keep total and free Testosterone at an even keel, while 300 mg and 600 mg/week...
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Zoe Mueller 24 minutes ago
Fat-free mass (aka lean body mass) increased by 5.3 kg (11.7 lb) in the 300 mg group and 8.5 kg (18....
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125 mg/week seemed to keep total and free Testosterone at an even keel, while 300 mg and 600 mg/week doses led to roughly a doubling and quadrupling of Testosterone levels. LH was suppressed at all doses while SHBG increased only with the highest two doses. Relative to changes in body composition, the lowest two doses of Testosterone led to a significant increase in fat mass (eeew!) while the middle dose (125 mg) once again led to no change.
Christopher Lee Member
access_time 60 minutes ago
125 mg/week seemed to keep total and free Testosterone at an even keel, while 300 mg and 600 mg/week doses led to roughly a doubling and quadrupling of Testosterone levels. LH was suppressed at all doses while SHBG increased only with the highest two doses. Relative to changes in body composition, the lowest two doses of Testosterone led to a significant increase in fat mass (eeew!) while the middle dose (125 mg) once again led to no change.
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Mason Rodriguez 14 minutes ago
Fat-free mass (aka lean body mass) increased by 5.3 kg (11.7 lb) in the 300 mg group and 8.5 kg (18....
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Sophia Chen 21 minutes ago
Following suit, the lowest two doses had basically no effect on thigh or quadriceps muscle volume, l...
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Fat-free mass (aka lean body mass) increased by 5.3 kg (11.7 lb) in the 300 mg group and 8.5 kg (18.7 lb) in the 600 mg group. The ratio of total body water to fat-free mass didn't change in any of the groups, indicating that the increases in fat-free mass were not a result of water retention. On to muscle size and performance.
Kevin Wang Member
access_time 52 minutes ago
Fat-free mass (aka lean body mass) increased by 5.3 kg (11.7 lb) in the 300 mg group and 8.5 kg (18.7 lb) in the 600 mg group. The ratio of total body water to fat-free mass didn't change in any of the groups, indicating that the increases in fat-free mass were not a result of water retention. On to muscle size and performance.
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Following suit, the lowest two doses had basically no effect on thigh or quadriceps muscle volume, leg press strength, or leg power. The 300 mg and 600 mg doses however led to significant increases in all of these parameters. Rather than confuse you with comma spices and annoyingly long sentences, here's what the data look like in table form (note: the % increases represent the change from baseline to week 20).
Jack Thompson Member
access_time 28 minutes ago
Following suit, the lowest two doses had basically no effect on thigh or quadriceps muscle volume, leg press strength, or leg power. The 300 mg and 600 mg doses however led to significant increases in all of these parameters. Rather than confuse you with comma spices and annoyingly long sentences, here's what the data look like in table form (note: the % increases represent the change from baseline to week 20).
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Luna Park 20 minutes ago
Dose Thigh muscle volume Quad muscle volume Leg strength Leg power 300 mg +9.9% +8.7% +16.4% +16.5% ...
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Elijah Patel 19 minutes ago
For years, athletes and scientists have nonetheless disagreed about the effect of anabolic steroids ...
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Dose Thigh muscle volume Quad muscle volume Leg strength Leg power 300 mg +9.9% +8.7% +16.4% +16.5% 600 mg +15.7% +14.4% +17.7% +22.6% Sexual function, visual-spatial cognition, mood and PSA levels didn't change in any of the groups. None of the blood chemistry or organ toxicity values (e.g., creatinine, bilirubin, ALT, AST, etc.) were altered, with the exception of dose-dependent decreases in HDL-C that ranged from 10-20% (5-8 mg/dL), and a 9.9% increase in hemoglobin in the 600 mg group (the absolute value of 155.7 g/L was still within normal clinical limits, though). Conclusions Back in 1985, a researcher named GB Forbes speculated that there was a linear relationship between Tstosterone dose and lean mass accretion.
James Smith Moderator
access_time 75 minutes ago
Dose Thigh muscle volume Quad muscle volume Leg strength Leg power 300 mg +9.9% +8.7% +16.4% +16.5% 600 mg +15.7% +14.4% +17.7% +22.6% Sexual function, visual-spatial cognition, mood and PSA levels didn't change in any of the groups. None of the blood chemistry or organ toxicity values (e.g., creatinine, bilirubin, ALT, AST, etc.) were altered, with the exception of dose-dependent decreases in HDL-C that ranged from 10-20% (5-8 mg/dL), and a 9.9% increase in hemoglobin in the 600 mg group (the absolute value of 155.7 g/L was still within normal clinical limits, though). Conclusions Back in 1985, a researcher named GB Forbes speculated that there was a linear relationship between Tstosterone dose and lean mass accretion.
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Ava White 7 minutes ago
For years, athletes and scientists have nonetheless disagreed about the effect of anabolic steroids ...
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For years, athletes and scientists have nonetheless disagreed about the effect of anabolic steroids on strength, muscle mass, and health status. The data from this thorough study support Forbes' assertion: weekly injections of Testosterone enanthate result in dose-dependent increases in muscle mass, muscle size, strength, and power. The downside is that HDL-C tends to take a nasty dip and at higher doses hemoglobin levels rise a smidgeon.
Mia Anderson Member
access_time 32 minutes ago
For years, athletes and scientists have nonetheless disagreed about the effect of anabolic steroids on strength, muscle mass, and health status. The data from this thorough study support Forbes' assertion: weekly injections of Testosterone enanthate result in dose-dependent increases in muscle mass, muscle size, strength, and power. The downside is that HDL-C tends to take a nasty dip and at higher doses hemoglobin levels rise a smidgeon.
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Ella Rodriguez 19 minutes ago
On a final note, the researchers were quick to point out that there were considerable differences in...
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Andrew Wilson 3 minutes ago
The most likely explanation is that Testosterone might differentially affect some (or all) of the ma...
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On a final note, the researchers were quick to point out that there were considerable differences in the response to Testosterone administration within each group. Why?
Luna Park Member
access_time 34 minutes ago
On a final note, the researchers were quick to point out that there were considerable differences in the response to Testosterone administration within each group. Why?
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Sophie Martin 19 minutes ago
The most likely explanation is that Testosterone might differentially affect some (or all) of the ma...
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Christopher Lee 16 minutes ago
As I read over this study for the tenth time, one thing is for sure: the athletes were right. Testos...
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The most likely explanation is that Testosterone might differentially affect some (or all) of the many factors that are thought to control muscle growth, including: nutritional status, physical activity level, glucocorticoid, thyroid, and growth hormone levels, polymorphisms of the androgen receptor, myostatin levels, etc. So even though this research was super thorough, it, like most studies, left scientists with more questions than answers.
Natalie Lopez Member
access_time 54 minutes ago
The most likely explanation is that Testosterone might differentially affect some (or all) of the many factors that are thought to control muscle growth, including: nutritional status, physical activity level, glucocorticoid, thyroid, and growth hormone levels, polymorphisms of the androgen receptor, myostatin levels, etc. So even though this research was super thorough, it, like most studies, left scientists with more questions than answers.
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Isabella Johnson 41 minutes ago
As I read over this study for the tenth time, one thing is for sure: the athletes were right. Testos...
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As I read over this study for the tenth time, one thing is for sure: the athletes were right. Testosterone does increase strength, power, and muscle size without negatively affecting the kidneys, liver or, prostate – you just have to take enough of it (i.e., at least 300 mg/week). Now that Testosterone has been shown to improve muscle mass in the elderly, in normal men, and in those with wasting disorders, I wonder how long it will take for its rogue social status to disappear?
Oliver Taylor Member
access_time 19 minutes ago
As I read over this study for the tenth time, one thing is for sure: the athletes were right. Testosterone does increase strength, power, and muscle size without negatively affecting the kidneys, liver or, prostate – you just have to take enough of it (i.e., at least 300 mg/week). Now that Testosterone has been shown to improve muscle mass in the elderly, in normal men, and in those with wasting disorders, I wonder how long it will take for its rogue social status to disappear?
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Judging how the media handled the recent "anabolic steroids in baseball" scandal, we may still be a few decades away... Reference Bhasin, S et al. (2001).
Sebastian Silva Member
access_time 60 minutes ago
Judging how the media handled the recent "anabolic steroids in baseball" scandal, we may still be a few decades away... Reference Bhasin, S et al. (2001).
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Isaac Schmidt 17 minutes ago
Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab 281:E11...
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Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab 281:E1172-E1181. Get The T Nation Newsletters Don&#039 t Miss Out Expert Insights To Get Stronger, Gain Muscle Faster, And Take Your Lifting To The Next Level related posts Alpha Life Tip Your Social Media – Motivating or Nah Are your fitness posts and photos motivating people or de-motivating them?
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Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab 281:E1172-E1181. Get The T Nation Newsletters Don&#039 t Miss Out Expert Insights To Get Stronger, Gain Muscle Faster, And Take Your Lifting To The Next Level related posts Alpha Life Tip Your Social Media – Motivating or Nah Are your fitness posts and photos motivating people or de-motivating them?
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It doesn't matter how much you exercise, it'll still hurt you. Here are 3 practical solutions. Health & Longevity, Living Better, Tips Mike Sheridan October 17 Alpha Life Tip Testosterone Levels Determine What You Buy Science determines the role testosterone plays in your purchases, your social status, and how much action you get.
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