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Robotic Surgery May Improve Outcomes in Mouth and Throat Cancer A Cedars-Sinai surgical team conducts a robotic surgery. Photo by Cedars-Sinai.
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Aria Nguyen Member
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Wednesday, 30 April 2025
Cedars-Sinai Study Finds Association Between Minimally Invasive Procedure for Oropharyngeal Cancer and Longer Survival for Patients Robotic surgery for patients with early stage, oropharyngeal squamous cell cancer is associated with improved health outcomes, including better long-term survival, according to a Cedars-Sinai study published Thursday in JAMA Oncology. Oropharyngeal cancer occurs in the back of the throat and includes the base of the tongue and tonsils. ­­ Transoral robotic surgery is a minimally invasive procedure in which a surgeon uses a computer-enhanced system to guide an endoscope – a flexible tube with a light and camera attached to it – to provide high-resolution, 3D images of the back of the mouth and throat, an area that is difficult to reach with conventional tools.
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Isaac Schmidt 3 minutes ago
Two robotically guided instruments, acting as a surgeon's arms, work around corners to safely r...
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James Smith 1 minutes ago
The authors found that the five-year overall survival rate for patients with early-stage disease who...
Two robotically guided instruments, acting as a surgeon's arms, work around corners to safely remove tumors from surrounding tissue. The Cedars-Sinai retrospective, observational study, which used data from the National Cancer Database, included 9,745 surgical patients – 2,694 of whom underwent transoral robotic surgery between 2010 and 2015.
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Mason Rodriguez Member
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Wednesday, 30 April 2025
The authors found that the five-year overall survival rate for patients with early-stage disease who underwent robotic surgery was 84.5%, compared with 80.3% for patients who had non-robotic surgery, after adjusting for differences in health and other characteristics of the two patient groups. "At a minimum, robotic surgery for oropharyngeal cancer patients seems safe and effective compared to what's been the standard of care for many years," said Zachary S.
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Victoria Lopez 1 minutes ago
Zumsteg, MD, assistant professor of Radiation Oncology at Cedars-Sinai, referring to standard surger...
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William Brown 2 minutes ago
Nguyen, MD, PhD, a resident in the Department of Radiation Oncology at Cedars-Sinai, is the study...
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Luna Park Member
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Wednesday, 30 April 2025
Zumsteg, MD, assistant professor of Radiation Oncology at Cedars-Sinai, referring to standard surgery, radiation therapy and chemotherapy. He is the study's senior and corresponding author. Anthony T.
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Jack Thompson 3 minutes ago
Nguyen, MD, PhD, a resident in the Department of Radiation Oncology at Cedars-Sinai, is the study...
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Nathan Chen 1 minutes ago
About 3,500 new cases of HPV-associated oropharyngeal cancers are diagnosed in women and ab...
Nguyen, MD, PhD, a resident in the Department of Radiation Oncology at Cedars-Sinai, is the study's lead author. Oropharyngeal cancer often is associated with the human papilloma virus, which is believed to cause 70% of oropharyngeal cancers in the United States, according to the Centers for Disease Control and Prevention.
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Thomas Anderson 1 minutes ago
About 3,500 new cases of HPV-associated oropharyngeal cancers are diagnosed in women and ab...
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Andrew Wilson Member
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Wednesday, 30 April 2025
About 3,500 new cases of HPV-associated oropharyngeal cancers are diagnosed in women and about 15,500 in men each year in the U.S. The Cedars-Sinai study observed that the proportion of patients undergoing transoral robotic surgery for early-stage oropharyngeal cancer increased dramatically after the U.S. Food and Drug Administration approved the surgery for that cancer in 2009 – from 18.3% in 2010 to 35.5% in 2015, according to the researchers' findings.
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Mason Rodriguez 13 minutes ago
Additionally, the proportion of facilities performing transoral robotic surgery during that same per...
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Sebastian Silva 30 minutes ago
In addition to increased overall survival rates, the researchers found that robotic surgery was asso...
Additionally, the proportion of facilities performing transoral robotic surgery during that same period more than doubled, from 6.3% to 13.9%. The nationwide increase in transoral robotic surgery for oropharyngeal cancer prompted the investigators to assess whether the theoretical benefits of robotic surgery for oropharyngeal cancer patients actually provide outcomes that are superior or equivalent to the standard treatments for that cancer type and others.
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Nathan Chen 1 minutes ago
In addition to increased overall survival rates, the researchers found that robotic surgery was asso...
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David Cohen 22 minutes ago
"Our purpose in doing this study was to see how this new technology, which has never been teste...
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Ethan Thomas Member
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18 minutes ago
Wednesday, 30 April 2025
In addition to increased overall survival rates, the researchers found that robotic surgery was associated with lower rates of positive surgical margins – 12.5% – compared with a rate of 20.3% for non-robotic surgery in patients with oropharyngeal cancer. Positive surgical margins refer to cancer cells that remain at the edge of tissue that has been surgically removed. Furthermore, robotic surgery was associated with less use of postoperative chemoradiation, at 28.6%, compared with 35.7% for patients who had non-robotic surgery.
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Lucas Martinez 13 minutes ago
"Our purpose in doing this study was to see how this new technology, which has never been teste...
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Christopher Lee Member
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Wednesday, 30 April 2025
"Our purpose in doing this study was to see how this new technology, which has never been tested in a randomized, controlled trial, has influenced patterns of treatment and outcomes since its FDA approval," Zumsteg said. "There is a learning curve with any new surgical technique, and new ones don't always translate into equal or improved outcomes." Referring to their study results as "hypothesis-generating," the researchers hope it will inform future randomized, controlled clinical trials," Nguyen said.
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Alexander Wang 37 minutes ago
"Meanwhile, it's reassuring to our patients that their survival rate is the same if not be...
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Charlotte Lee Member
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11 minutes ago
Wednesday, 30 April 2025
"Meanwhile, it's reassuring to our patients that their survival rate is the same if not better with robotic surgery and they have the potential for a better quality of life," Nguyen said. The study was supported by Cedars-Sinai Cancer. The authors report no conflicts of interest related to this work.
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Lucas Martinez Moderator
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Wednesday, 30 April 2025
Read a cancer survivor's empowering story on the Cedars-Sinai blog: "Climbing Beyond Cancer"
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Cedars-Sinai Study Finds Association Between Minimally Invasive Procedure for Oropharyngeal Cancer a...