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% Researchers Harness Bacterial Stealth Strategy to Fight Inflammation Skip to main content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Menu Close Call 1-800-CEDARS-1 toggle search form Close 10 December 2015 02:14 AM America/Los_Angeles Researchers Harness Bacterial Stealth Strategy to Fight Inflammation New Study in Cell Host &amp Microbe Could Lead to New Treatments for Inflammatory Diseases Such as Arthritis Emphysema and Colitis Contact: Sally Stewart Email: sally.stewart@cshs.org Los Angeles - Dec. 10, 2015 - In their quest to find new therapies for patients with inflammatory diseases, Cedars-Sinai investigators have discovered a powerful strategy employed by bacteria that could be used to develop new inflammation-fighting treatments. In the December issue of Cell Host & Microbe, the researchers explain that bacteria face many of the same inflammatory challenges with infections as humans face with inflammatory diseases such as diabetes, rheumatoid arthritis and pulmonary emphysema.
Isaac Schmidt Member
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% Researchers Harness Bacterial Stealth Strategy to Fight Inflammation Skip to main content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Menu Close Call 1-800-CEDARS-1 toggle search form Close 10 December 2015 02:14 AM America/Los_Angeles Researchers Harness Bacterial Stealth Strategy to Fight Inflammation New Study in Cell Host &amp Microbe Could Lead to New Treatments for Inflammatory Diseases Such as Arthritis Emphysema and Colitis Contact: Sally Stewart Email: [email protected] Los Angeles - Dec. 10, 2015 - In their quest to find new therapies for patients with inflammatory diseases, Cedars-Sinai investigators have discovered a powerful strategy employed by bacteria that could be used to develop new inflammation-fighting treatments. In the December issue of Cell Host & Microbe, the researchers explain that bacteria face many of the same inflammatory challenges with infections as humans face with inflammatory diseases such as diabetes, rheumatoid arthritis and pulmonary emphysema.
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As a result, bacteria develop anti-inflammatory strategies of their own to stay alive in the human body. "This study suggests that bacteria's own tools to survive infection in the human body could potentially be used as therapeutic agents for many inflammatory diseases," Stacey Kolar, PhD, first author of the study.
William Brown Member
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As a result, bacteria develop anti-inflammatory strategies of their own to stay alive in the human body. "This study suggests that bacteria's own tools to survive infection in the human body could potentially be used as therapeutic agents for many inflammatory diseases," Stacey Kolar, PhD, first author of the study.
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William Brown 7 minutes ago
The findings represent an important step in ongoing efforts to develop effective treatments for infl...
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The findings represent an important step in ongoing efforts to develop effective treatments for inflammatory diseases that affect millions worldwide. Current treatments for Crohn's disease, hepatitis and other inflammatory conditions are aimed at diminishing symptoms but may not address the root cause or prompt inflammation to subside.
Hannah Kim Member
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The findings represent an important step in ongoing efforts to develop effective treatments for inflammatory diseases that affect millions worldwide. Current treatments for Crohn's disease, hepatitis and other inflammatory conditions are aimed at diminishing symptoms but may not address the root cause or prompt inflammation to subside.
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Natalie Lopez 3 minutes ago
Central to the new finding is a sugar molecule called hyaluronan. This molecule, found in most human...
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Joseph Kim 2 minutes ago
The investigators found that many bacteria produce a different version of the enzyme that destroys t...
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Central to the new finding is a sugar molecule called hyaluronan. This molecule, found in most human tissues, lubricates joints and can be used as a filler for sagging, aging skin. The immune system fights infection by relying on a specific enzyme to break down hyaluronan into fragments which signal to the immune system that the body is under attack and to crank up inflammation.
Sofia Garcia Member
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Central to the new finding is a sugar molecule called hyaluronan. This molecule, found in most human tissues, lubricates joints and can be used as a filler for sagging, aging skin. The immune system fights infection by relying on a specific enzyme to break down hyaluronan into fragments which signal to the immune system that the body is under attack and to crank up inflammation.
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The investigators found that many bacteria produce a different version of the enzyme that destroys the sugar molecule fragments. "By doing so, the bacterial enzyme prevents the immune system from turning up inflammation," said George Liu, MD, PhD, senior author of the study and a pediatric infectious diseases physician at Cedars-Sinai's Maxine Dunitz Children's Health Center and the F.
Grace Liu Member
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The investigators found that many bacteria produce a different version of the enzyme that destroys the sugar molecule fragments. "By doing so, the bacterial enzyme prevents the immune system from turning up inflammation," said George Liu, MD, PhD, senior author of the study and a pediatric infectious diseases physician at Cedars-Sinai's Maxine Dunitz Children's Health Center and the F.
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Widjaja Inflammatory Bowel and Immunobiology Research Institute. When the sugar molecule fragments are broken down by bacteria, substances called hyaluronan disaccharides further block inflammatory responses by the immune system.
Sebastian Silva Member
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Widjaja Inflammatory Bowel and Immunobiology Research Institute. When the sugar molecule fragments are broken down by bacteria, substances called hyaluronan disaccharides further block inflammatory responses by the immune system.
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Noah Davis 2 minutes ago
"The net result is that the bacteria have developed a powerful way to shut down inflammation an...
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"The net result is that the bacteria have developed a powerful way to shut down inflammation and evade detection," Liu said. Because hyaluronan disaccharides and bacterial enzymes that degrade the sugar molecule both uniquely dampen the immune system, the investigators tested whether the same strategy could be used to block inflammation in the lungs of laboratory mice.
Julia Zhang Member
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"The net result is that the bacteria have developed a powerful way to shut down inflammation and evade detection," Liu said. Because hyaluronan disaccharides and bacterial enzymes that degrade the sugar molecule both uniquely dampen the immune system, the investigators tested whether the same strategy could be used to block inflammation in the lungs of laboratory mice.
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Mia Anderson 2 minutes ago
"What we saw was a complete absence of inflammation when lung tissues were inspected under the ...
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"What we saw was a complete absence of inflammation when lung tissues were inspected under the microscope," Kolar said. "Treatment with the disaccharides or with the bacterial enzyme dramatically dampened markers of inflammation." In future studies, the researchers plan to test their new therapeutics against an array of human inflammatory diseases.
Isaac Schmidt Member
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"What we saw was a complete absence of inflammation when lung tissues were inspected under the microscope," Kolar said. "Treatment with the disaccharides or with the bacterial enzyme dramatically dampened markers of inflammation." In future studies, the researchers plan to test their new therapeutics against an array of human inflammatory diseases.
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James Smith 38 minutes ago
The study was supported by a Burroughs-Wellcome Career Award and a National Institutes of Health res...
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The study was supported by a Burroughs-Wellcome Career Award and a National Institutes of Health research grant under award number T32 AI89553-3 and AI 10383-9. From left to right: A view of a normal lung with open air sacs, an inflamed lung with reduced air sacs and a treated lung with open air sacs.
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The study was supported by a Burroughs-Wellcome Career Award and a National Institutes of Health research grant under award number T32 AI89553-3 and AI 10383-9. From left to right: A view of a normal lung with open air sacs, an inflamed lung with reduced air sacs and a treated lung with open air sacs.
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Share this release Researchers Harness Bacterial Stealth Strategy to Fight Inflammation Share on: Twitter Share on: Facebook Share on: LinkedIn Search Our Newsroom Social media Visit our Facebook page (opens in new window) Follow us on Twitter (opens in new window) Visit our Youtube profile (opens in new window) (opens in new window) Latest news 07 Oct 2022 - HealthDay: Black Women Less Likely to Get Laparoscopic Fibroid Surgeries 07 Oct 2022 - Faculty Publications: Sept. 29-Oct. 6 07 Oct 2022 - Fine-Tuning Organ-Chip Technology 06 Oct 2022 - KCRW: Want New Omicron Booster?
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Share this release Researchers Harness Bacterial Stealth Strategy to Fight Inflammation Share on: Twitter Share on: Facebook Share on: LinkedIn Search Our Newsroom Social media Visit our Facebook page (opens in new window) Follow us on Twitter (opens in new window) Visit our Youtube profile (opens in new window) (opens in new window) Latest news 07 Oct 2022 - HealthDay: Black Women Less Likely to Get Laparoscopic Fibroid Surgeries 07 Oct 2022 - Faculty Publications: Sept. 29-Oct. 6 07 Oct 2022 - Fine-Tuning Organ-Chip Technology 06 Oct 2022 - KCRW: Want New Omicron Booster?
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As a result, bacteria develop anti-inflammatory strategies of their own to stay alive in the human b...
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