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%Start Research Areas - J. Kim Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory J.
Sebastian Silva Member
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%Start Research Areas - J. Kim Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory J.
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Kim Lab Back to J. Kim Lab Publications Research Areas Research Areas Molecular Mechanism and Biomarkers of Interstitial Cystitis IC One of the major focus areas in the J. Kim Laboratory is the study of the molecular signature for the diagnosis of IC.
Mia Anderson Member
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Kim Lab Back to J. Kim Lab Publications Research Areas Research Areas Molecular Mechanism and Biomarkers of Interstitial Cystitis IC One of the major focus areas in the J. Kim Laboratory is the study of the molecular signature for the diagnosis of IC.
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The goal of our IC studies is to identify and validate sensitive and noninvasive diagnostic biomarkers using urine specimens that stratify IC patients from healthy subjects. IC is a debilitating condition that presents with a constellation of symptoms including bladder pain, urinary urgency, frequency, nocturia and small voided volumes in the absence of other identifiable etiologies.
Oliver Taylor Member
access_time 12 minutes ago
The goal of our IC studies is to identify and validate sensitive and noninvasive diagnostic biomarkers using urine specimens that stratify IC patients from healthy subjects. IC is a debilitating condition that presents with a constellation of symptoms including bladder pain, urinary urgency, frequency, nocturia and small voided volumes in the absence of other identifiable etiologies.
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Mia Anderson 6 minutes ago
Approximately 3 to 8 million women (up to 7 percent of women in the US) are diagnosed annually as IC...
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Alexander Wang 3 minutes ago
Thus, differentiating IC from other conditions is still a diagnostic challenge, and objective diagno...
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Approximately 3 to 8 million women (up to 7 percent of women in the US) are diagnosed annually as IC, and over 80 percent of IC patients are women. There is no gold standard for IC diagnosis, and in general, it takes approximately four to five years from the first office visit to obtain a definitive diagnosis of IC.
Sofia Garcia Member
access_time 8 minutes ago
Approximately 3 to 8 million women (up to 7 percent of women in the US) are diagnosed annually as IC, and over 80 percent of IC patients are women. There is no gold standard for IC diagnosis, and in general, it takes approximately four to five years from the first office visit to obtain a definitive diagnosis of IC.
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Amelia Singh 7 minutes ago
Thus, differentiating IC from other conditions is still a diagnostic challenge, and objective diagno...
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Julia Zhang 3 minutes ago
Cisplatin Resistance of Muscle Invasive Bladder Cancer The incidence of bladder cancer recurrence fo...
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Thus, differentiating IC from other conditions is still a diagnostic challenge, and objective diagnostic markers are urgently needed to improve prospects for clinical care. Recently, we have obtained evidence that levels of specific metabolites are perturbed in urine specimens from IC patients.
Dylan Patel Member
access_time 15 minutes ago
Thus, differentiating IC from other conditions is still a diagnostic challenge, and objective diagnostic markers are urgently needed to improve prospects for clinical care. Recently, we have obtained evidence that levels of specific metabolites are perturbed in urine specimens from IC patients.
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Isaac Schmidt 9 minutes ago
Cisplatin Resistance of Muscle Invasive Bladder Cancer The incidence of bladder cancer recurrence fo...
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Cisplatin Resistance of Muscle Invasive Bladder Cancer The incidence of bladder cancer recurrence following chemotherapy is high, thus the poor survival rate. Therefore, bladder cancer biomarkers that could predict a patient response to chemotherapy and probable disease course would allow better treatment strategies for individual patients.
Ethan Thomas Member
access_time 18 minutes ago
Cisplatin Resistance of Muscle Invasive Bladder Cancer The incidence of bladder cancer recurrence following chemotherapy is high, thus the poor survival rate. Therefore, bladder cancer biomarkers that could predict a patient response to chemotherapy and probable disease course would allow better treatment strategies for individual patients.
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The goal of our bladder cancer study is to develop such predictive markers of bladder cancer that identify patients who are poor chemotherapy candidates, as well as to identify potential mechanism for re-sensitizing nonresponsive bladder cancers to chemotherapy. Cholesterol Metabolism in Urological Diseases Although the public health burden is considerable, the etiology of benign prostatic diseases, such as benign prostatic hyperplasia (BPH), is poorly understood.
Isaac Schmidt Member
access_time 28 minutes ago
The goal of our bladder cancer study is to develop such predictive markers of bladder cancer that identify patients who are poor chemotherapy candidates, as well as to identify potential mechanism for re-sensitizing nonresponsive bladder cancers to chemotherapy. Cholesterol Metabolism in Urological Diseases Although the public health burden is considerable, the etiology of benign prostatic diseases, such as benign prostatic hyperplasia (BPH), is poorly understood.
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Prostate health is highly controlled by genome and individual lifestyle. The cholesterol-enriched Western diet may be a risk factor for prostate health.
Alexander Wang Member
access_time 40 minutes ago
Prostate health is highly controlled by genome and individual lifestyle. The cholesterol-enriched Western diet may be a risk factor for prostate health.
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Recent epidemiologic studies have suggested that cholesterol-lowering drugs (e.g., 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors) may lower prostate cancer progression; however, very limited studies have been performed on benign prostate diseases. In a previous J.
Andrew Wilson Member
access_time 9 minutes ago
Recent epidemiologic studies have suggested that cholesterol-lowering drugs (e.g., 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors) may lower prostate cancer progression; however, very limited studies have been performed on benign prostate diseases. In a previous J.
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Charlotte Lee 2 minutes ago
Kim Laboratory study, a global gene expression profile, using a novel method of raising and lowering...
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Luna Park 2 minutes ago
Since several cholesterol-targeting agents (e.g., ezetimibe) are clinically available, the results f...
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Kim Laboratory study, a global gene expression profile, using a novel method of raising and lowering circulating cholesterol in mice, has suggested that cholesterol can mediate reactive changes in the prostate, promoting disease. The functional analysis has revealed the molecular mechanism by which the normal prostate in situ, and prostatic epithelial cells in culture, sense and respond to the altered cholesterol levels. We also suggested that ATF3, an early responsive gene and a transcription factor, is a modulator of cholesterol response in prostate cells, thus triggering biological effects.
Liam Wilson Member
access_time 20 minutes ago
Kim Laboratory study, a global gene expression profile, using a novel method of raising and lowering circulating cholesterol in mice, has suggested that cholesterol can mediate reactive changes in the prostate, promoting disease. The functional analysis has revealed the molecular mechanism by which the normal prostate in situ, and prostatic epithelial cells in culture, sense and respond to the altered cholesterol levels. We also suggested that ATF3, an early responsive gene and a transcription factor, is a modulator of cholesterol response in prostate cells, thus triggering biological effects.
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Since several cholesterol-targeting agents (e.g., ezetimibe) are clinically available, the results from this study are of direct relevance to human prostate health, and the cholesterol-lowing drugs may be a tremendous health benefit, in particular, to prostate health. Studies in the J. Kim Laboratory are supported by several active grants sponsored by the National Institutes of Health (e.g., NIDDK and NCI), the Spielberg Prostate Cancer Discovery Fund and the Interstitial Cystitis Association Research Fund.
Andrew Wilson Member
access_time 22 minutes ago
Since several cholesterol-targeting agents (e.g., ezetimibe) are clinically available, the results from this study are of direct relevance to human prostate health, and the cholesterol-lowing drugs may be a tremendous health benefit, in particular, to prostate health. Studies in the J. Kim Laboratory are supported by several active grants sponsored by the National Institutes of Health (e.g., NIDDK and NCI), the Spielberg Prostate Cancer Discovery Fund and the Interstitial Cystitis Association Research Fund.
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Nathan Chen 21 minutes ago
J. Kim is a former American Urologic Association Foundation Scholar (now Urology Care Foundation), E...
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J. Kim is a former American Urologic Association Foundation Scholar (now Urology Care Foundation), Edwin Beer Scholar (New York Academy of Medicine), Eleanor and Miles Shore Scholar (Harvard Medical School) and the “Imagine No IC” Research Scholar (Interstitial Cystitis Association Research Foundation).
Oliver Taylor Member
access_time 36 minutes ago
J. Kim is a former American Urologic Association Foundation Scholar (now Urology Care Foundation), Edwin Beer Scholar (New York Academy of Medicine), Eleanor and Miles Shore Scholar (Harvard Medical School) and the “Imagine No IC” Research Scholar (Interstitial Cystitis Association Research Foundation).
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Jack Thompson 24 minutes ago
Contact the J Kim Lab 8700 Beverly Blvd. Davis Building, Room 5094A/B Los Angeles, CA 90048 310-423...
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Kevin Wang 6 minutes ago
Research Areas - J. Kim Lab Cedars-Sinai Skip to content Close Select your preferred language Eng...
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Contact the J Kim Lab 8700 Beverly Blvd. Davis Building, Room 5094A/B Los Angeles, CA 90048 310-423-7168 Send a Message Please ensure Javascript is enabled for purposes of website accessibility
Joseph Kim Member
access_time 65 minutes ago
Contact the J Kim Lab 8700 Beverly Blvd. Davis Building, Room 5094A/B Los Angeles, CA 90048 310-423-7168 Send a Message Please ensure Javascript is enabled for purposes of website accessibility
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Lily Watson 25 minutes ago
Research Areas - J. Kim Lab Cedars-Sinai Skip to content Close Select your preferred language Eng...
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Sophie Martin 45 minutes ago
Kim Lab Back to J. Kim Lab Publications Research Areas Research Areas Molecular Mechanism and ...
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