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%Begin New Drug Blocks Pancreatic Cancer Growth in Mice Study Finds Skip to main content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Menu Close Call 1-800-CEDARS-1 toggle search form Close Los Angeles, 25 September 2018 06:00 AM America/Los_Angeles New Drug Blocks Pancreatic Cancer Growth in Mice Study Finds Microscopic view of pancreatic cancer cells. Image by Getty Images. Microscipic view of pancreatic cancer cells.
William Brown Member
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%Begin New Drug Blocks Pancreatic Cancer Growth in Mice Study Finds Skip to main content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Menu Close Call 1-800-CEDARS-1 toggle search form Close Los Angeles, 25 September 2018 06:00 AM America/Los_Angeles New Drug Blocks Pancreatic Cancer Growth in Mice Study Finds Microscopic view of pancreatic cancer cells. Image by Getty Images. Microscipic view of pancreatic cancer cells.
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Charlotte Lee 1 minutes ago
A newly developed drug can prevent the most common type of pancreatic cancer from growing and spread...
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Mia Anderson 1 minutes ago
"If the results are confirmed in humans, we could have a drug with the potential to significant...
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A newly developed drug can prevent the most common type of pancreatic cancer from growing and spreading in laboratory mice, according to a study led by Cedars-Sinai. The study, published recently in the journal Gastroenterology, also demonstrated in mice that the drug, called Metavert, can prevent patients from developing a resistance to currently used pancreatic cancer chemotherapies. "This is an exciting step toward improving survival rates in pancreatic cancer patients," said study lead author Mouad Edderkaoui, PhD, assistant professor of Medicine and Biomedical Sciences at the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai.
Mason Rodriguez Member
access_time 4 minutes ago
A newly developed drug can prevent the most common type of pancreatic cancer from growing and spreading in laboratory mice, according to a study led by Cedars-Sinai. The study, published recently in the journal Gastroenterology, also demonstrated in mice that the drug, called Metavert, can prevent patients from developing a resistance to currently used pancreatic cancer chemotherapies. "This is an exciting step toward improving survival rates in pancreatic cancer patients," said study lead author Mouad Edderkaoui, PhD, assistant professor of Medicine and Biomedical Sciences at the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai.
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Sophia Chen 1 minutes ago
"If the results are confirmed in humans, we could have a drug with the potential to significant...
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Lily Watson 4 minutes ago
will be diagnosed with the disease and more than 44,000 will die, making it one of the deadliest can...
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"If the results are confirmed in humans, we could have a drug with the potential to significantly extend the lives of patients with pancreatic ductal adenocarcinoma (PDAC), which is very difficult to treat." Pancreatic cancer is the third-leading cause of cancer-related death in the United States, according to the American Cancer Society. This year, about 55,000 people in the U.S.
David Cohen Member
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"If the results are confirmed in humans, we could have a drug with the potential to significantly extend the lives of patients with pancreatic ductal adenocarcinoma (PDAC), which is very difficult to treat." Pancreatic cancer is the third-leading cause of cancer-related death in the United States, according to the American Cancer Society. This year, about 55,000 people in the U.S.
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Andrew Wilson 1 minutes ago
will be diagnosed with the disease and more than 44,000 will die, making it one of the deadliest can...
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Ava White 7 minutes ago
Ninety-five percent of pancreatic cancer patients are diagnosed with PDAC, which develops from cells...
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will be diagnosed with the disease and more than 44,000 will die, making it one of the deadliest cancers. The pancreatic cancer five-year survival rate is 7 percent.
Charlotte Lee Member
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will be diagnosed with the disease and more than 44,000 will die, making it one of the deadliest cancers. The pancreatic cancer five-year survival rate is 7 percent.
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Ninety-five percent of pancreatic cancer patients are diagnosed with PDAC, which develops from cells lining small tubes in the pancreas. PDAC can be difficult to treat because the cancer cells prompt normal cells that reside in the pancreas-called stellate cells-to produce pancreatic scar tissue.
Luna Park Member
access_time 10 minutes ago
Ninety-five percent of pancreatic cancer patients are diagnosed with PDAC, which develops from cells lining small tubes in the pancreas. PDAC can be difficult to treat because the cancer cells prompt normal cells that reside in the pancreas-called stellate cells-to produce pancreatic scar tissue.
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Ella Rodriguez 6 minutes ago
Scar tissue makes it difficult for chemotherapy agents and blood to enter the pancreas, said study s...
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Daniel Kumar 5 minutes ago
Additionally, the activity levels of certain enzymes rev up, fueling resistance to cancer treatments...
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Scar tissue makes it difficult for chemotherapy agents and blood to enter the pancreas, said study senior author Stephen J. Pandol, MD, director of Basic and Translational Pancreas Research at Cedars-Sinai. The cancer and stellate cell interaction also creates an environment that stimulates local tumor growth and cancer spread to distant sites in the body, said Pandol, a professor of Medicine at Cedars-Sinai.
Mason Rodriguez Member
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Scar tissue makes it difficult for chemotherapy agents and blood to enter the pancreas, said study senior author Stephen J. Pandol, MD, director of Basic and Translational Pancreas Research at Cedars-Sinai. The cancer and stellate cell interaction also creates an environment that stimulates local tumor growth and cancer spread to distant sites in the body, said Pandol, a professor of Medicine at Cedars-Sinai.
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Dylan Patel 16 minutes ago
Additionally, the activity levels of certain enzymes rev up, fueling resistance to cancer treatments...
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Natalie Lopez 16 minutes ago
They discovered that Metavert blocked drug resistance and also significantly boosted the positive ef...
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Additionally, the activity levels of certain enzymes rev up, fueling resistance to cancer treatments. "I've seen patients who respond to therapy for a while, and then the disease takes off because the cancer becomes smart-it blocks chemotherapy from working," Pandol said. "Metavert targets that action." Over a four-year period, the investigators designed and synthesized new chemicals that inhibit cancer cell activity.
Andrew Wilson Member
access_time 7 minutes ago
Additionally, the activity levels of certain enzymes rev up, fueling resistance to cancer treatments. "I've seen patients who respond to therapy for a while, and then the disease takes off because the cancer becomes smart-it blocks chemotherapy from working," Pandol said. "Metavert targets that action." Over a four-year period, the investigators designed and synthesized new chemicals that inhibit cancer cell activity.
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Zoe Mueller 4 minutes ago
They discovered that Metavert blocked drug resistance and also significantly boosted the positive ef...
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They discovered that Metavert blocked drug resistance and also significantly boosted the positive effects of radiation and two chemotherapy agents commonly used in humans. In one of the mouse studies, Metavert increased the survival rate by about 50 percent.
Thomas Anderson Member
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They discovered that Metavert blocked drug resistance and also significantly boosted the positive effects of radiation and two chemotherapy agents commonly used in humans. In one of the mouse studies, Metavert increased the survival rate by about 50 percent.
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The investigators currently are developing a version of the drug to test in humans, Pandol said. Funding: Research reported in this publication was supported by the National Institutes of Health (National Institute on Alcohol Abuse and Alcoholism) grants under award numbers K01 AA019996 and P50AA011999; a National Cancer Institute grant, under award number P01CA163200; a Department of Veterans Affairs grant; a Hirshberg Foundation Award; and the Samuel Oschin Comprehensive Cancer Institute Developmental Funds for Liver Metastasis Team Grant Research Award. Disclosure: The authors Edderkaoui; Pandol; Aida Habtezion, MD, MSc; and Ramachandran Murali, PhD, disclose their relationship with Avenzoar Pharmaceutical.
James Smith Moderator
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The investigators currently are developing a version of the drug to test in humans, Pandol said. Funding: Research reported in this publication was supported by the National Institutes of Health (National Institute on Alcohol Abuse and Alcoholism) grants under award numbers K01 AA019996 and P50AA011999; a National Cancer Institute grant, under award number P01CA163200; a Department of Veterans Affairs grant; a Hirshberg Foundation Award; and the Samuel Oschin Comprehensive Cancer Institute Developmental Funds for Liver Metastasis Team Grant Research Award. Disclosure: The authors Edderkaoui; Pandol; Aida Habtezion, MD, MSc; and Ramachandran Murali, PhD, disclose their relationship with Avenzoar Pharmaceutical.
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Edderkaoui, Pandol and Murali are co-inventors in the patent related to Metavert. Other authors have no conflicts of interest.
Harper Kim Member
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Edderkaoui, Pandol and Murali are co-inventors in the patent related to Metavert. Other authors have no conflicts of interest.
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