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 <h1>Immunoglobulins and Immunoglobulin Blood Tests  Function and Purpose</h1>Medically reviewed by William C Lloyd III, MD, FACS — By Daniel Yetman on October 14, 2022Immunoglobulins, also called antibodies, are molecules produced by white blood cells that help your body defend against infections and cancer.
%Begin Immunoglobulins and Immunoglobulin Tests: Function and Clinical Uses Health ConditionsFeaturedBreast CancerIBD MigraineMultiple Sclerosis (MS)Rheumatoid ArthritisType 2 DiabetesSponsored TopicsArticlesAcid RefluxADHDAllergiesAlzheimer's & DementiaBipolar DisorderCancerCrohn's DiseaseChronic PainCold & FluCOPDDepressionFibromyalgiaHeart DiseaseHigh CholesterolHIVHypertensionIPFOsteoarthritisPsoriasisSkin Disorders and CareSTDsDiscoverWellness TopicsNutritionFitnessSkin CareSexual HealthWomen's HealthMental HealthSleepOriginal SeriesFresh Food FastDiagnosis DiariesYou’re Not AlonePresent TenseVideo SeriesYouth in FocusHealthy HarvestNo More SilenceFuture of HealthPlanHealth ChallengesMindful EatingSugar SavvyMove Your BodyGut HealthMood FoodsAlign Your SpineFind CarePrimary CareMental HealthOB-GYNDermatologistsNeurologistsCardiologistsOrthopedistsLifestyle QuizzesWeight ManagementAm I Depressed? A Quiz for TeensAre You a Workaholic?How Well Do You Sleep?Tools & ResourcesHealth NewsFind a DietFind Healthy SnacksDrugs A-ZHealth A-ZConnectFind Your Bezzy CommunityBreast CancerInflammatory Bowel DiseasePsoriatic ArthritisMigraineMultiple SclerosisPsoriasisFollow us on social mediaShopProducts by ConditionInsomniaStress ReliefBack PainNeck PainSleep ApneaHot SleepersAllergiesPain ReliefProduct ReviewsVitamins & SupplementsSleepMental HealthNutritionAt-Home TestingCBDMen’s HealthWomen’s HealthHealth ConditionsDiscoverPlanConnectShopSubscribe

Immunoglobulins and Immunoglobulin Blood Tests Function and Purpose

Medically reviewed by William C Lloyd III, MD, FACS — By Daniel Yetman on October 14, 2022Immunoglobulins, also called antibodies, are molecules produced by white blood cells that help your body defend against infections and cancer.
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Aria Nguyen 1 minutes ago
Their primary function is to bind to foreign cells like bacteria and viruses. This binding helps neu...
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Their primary function is to bind to foreign cells like bacteria and viruses. This binding helps neutralize the foreign cell and signals to your white blood cells to destroy them.
Their primary function is to bind to foreign cells like bacteria and viruses. This binding helps neutralize the foreign cell and signals to your white blood cells to destroy them.
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Alexander Wang 3 minutes ago
Humans have five types of immunoglobulins. Immunoglobulin levels that are higher or lower than norma...
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Humans have five types of immunoglobulins. Immunoglobulin levels that are higher or lower than normal can indicate an underlying medical condition. For example, a type of cancer called multiple myeloma is often associated with elevated levels of immunoglobulins, and kidney disease sometimes causes low levels.
Humans have five types of immunoglobulins. Immunoglobulin levels that are higher or lower than normal can indicate an underlying medical condition. For example, a type of cancer called multiple myeloma is often associated with elevated levels of immunoglobulins, and kidney disease sometimes causes low levels.
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James Smith 1 minutes ago
Doctors sometimes treat low immunoglobulin levels with an intravenous (IV) immunoglobulin infusion. ...
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Doctors sometimes treat low immunoglobulin levels with an intravenous (IV) immunoglobulin infusion. Read on to learn more about immunoglobulins, including how they help your body mount a defense against infections and why doctors use tests to measure your immunoglobulin levels. <h2>What are immunoglobulins </h2>
Immunoglobulins are Y-shaped molecules made up of sugar and protein produced by plasma cells, a type of white blood cell.
Doctors sometimes treat low immunoglobulin levels with an intravenous (IV) immunoglobulin infusion. Read on to learn more about immunoglobulins, including how they help your body mount a defense against infections and why doctors use tests to measure your immunoglobulin levels.

What are immunoglobulins

Immunoglobulins are Y-shaped molecules made up of sugar and protein produced by plasma cells, a type of white blood cell.
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Alexander Wang 4 minutes ago
They have three main functions:preventing foreign invaders from entering cells by neutralizing themc...
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Daniel Kumar 6 minutes ago
Each antibody only binds with one particular type of foreign molecule.

What are plasma cells

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They have three main functions:preventing foreign invaders from entering cells by neutralizing themcoating foreign invaders to tag them for destruction by white blood cells called macrophagestriggering destruction of foreign invaders by stimulating other immune responses
The tip of immunoglobulins contains a highly variable region called a paratope. The paratope binds to sections of foreign molecules called epitopes like a lock and key. The tip of the paratope contains a highly variable region that allows for your body to produce millions of types of antibodies.
They have three main functions:preventing foreign invaders from entering cells by neutralizing themcoating foreign invaders to tag them for destruction by white blood cells called macrophagestriggering destruction of foreign invaders by stimulating other immune responses The tip of immunoglobulins contains a highly variable region called a paratope. The paratope binds to sections of foreign molecules called epitopes like a lock and key. The tip of the paratope contains a highly variable region that allows for your body to produce millions of types of antibodies.
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Daniel Kumar 2 minutes ago
Each antibody only binds with one particular type of foreign molecule.

What are plasma cells

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Hannah Kim 8 minutes ago
They have the capacity to generate mass quantities of immunoglobulins that are programmed to recogni...
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Each antibody only binds with one particular type of foreign molecule. <h3>What are plasma cells </h3>
Plasma cells are activated B cells.
Each antibody only binds with one particular type of foreign molecule.

What are plasma cells

Plasma cells are activated B cells.
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Scarlett Brown 3 minutes ago
They have the capacity to generate mass quantities of immunoglobulins that are programmed to recogni...
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Brandon Kumar 2 minutes ago
Lymphoid stem cells can become three types of white blood cells that play critical roles in your ada...
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They have the capacity to generate mass quantities of immunoglobulins that are programmed to recognize a specific epitope (foreign molecule). Your blood consists of three types of blood cells:red blood cells that carry oxygen around your bodyplatelets that help your blood clot after an injurywhite blood cells that protect your body from foreign invaders and cancers
All blood cells come from special cells called hematopoietic stem cells found in your bone marrow. These cells can become two other types of cells called myeloid stem cells or lymphoid stem cells.
They have the capacity to generate mass quantities of immunoglobulins that are programmed to recognize a specific epitope (foreign molecule). Your blood consists of three types of blood cells:red blood cells that carry oxygen around your bodyplatelets that help your blood clot after an injurywhite blood cells that protect your body from foreign invaders and cancers All blood cells come from special cells called hematopoietic stem cells found in your bone marrow. These cells can become two other types of cells called myeloid stem cells or lymphoid stem cells.
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Chloe Santos 11 minutes ago
Lymphoid stem cells can become three types of white blood cells that play critical roles in your ada...
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Lymphoid stem cells can become three types of white blood cells that play critical roles in your adaptive immunity:Natural killer cells: contain enzymes to destroy cancer cells or virusesT cells: destroy infected cells and activate other immune cellsB cells: become plasma cells when activated by foreign invaders and produce Immunoglobulins
 <h2>What are the most common types  classes  of immunoglobulin </h2>
Immunoglobulins are made up of two molecules called light chains and two called heavy chains. Five types of immunoglobins are found in humans. They’re named after the type of heavy chain they contain:IgM: Provides rapid defense against infectious diseases.IgG: Provides most of the immunoglobin-based immunity against foreign molecules but has a slower effect than IgG.IgA: Provides defense against infectious agents and is found mostly in your mucus membranes.
Lymphoid stem cells can become three types of white blood cells that play critical roles in your adaptive immunity:Natural killer cells: contain enzymes to destroy cancer cells or virusesT cells: destroy infected cells and activate other immune cellsB cells: become plasma cells when activated by foreign invaders and produce Immunoglobulins

What are the most common types classes of immunoglobulin

Immunoglobulins are made up of two molecules called light chains and two called heavy chains. Five types of immunoglobins are found in humans. They’re named after the type of heavy chain they contain:IgM: Provides rapid defense against infectious diseases.IgG: Provides most of the immunoglobin-based immunity against foreign molecules but has a slower effect than IgG.IgA: Provides defense against infectious agents and is found mostly in your mucus membranes.
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It protects the surfaces of your respiratory, digestive, and urinary systems.IgE: Provides protection against parasites. It also triggers histamine release from white blood cells called mast cells and basophils to trigger allergic reactions.IgD: Has a largely unknown function.
It protects the surfaces of your respiratory, digestive, and urinary systems.IgE: Provides protection against parasites. It also triggers histamine release from white blood cells called mast cells and basophils to trigger allergic reactions.IgD: Has a largely unknown function.
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Joseph Kim 9 minutes ago
It may serve as a receptor on B cells that haven’t been previously exposed to foreign molecules. <...
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It may serve as a receptor on B cells that haven’t been previously exposed to foreign molecules. <h2>How are immunoglobulins used in the field of medicine </h2>
Immunoglobulin levels are useful biomarkers for monitoring many different diseases, including immunodeficiencies and autoimmune diseases.
It may serve as a receptor on B cells that haven’t been previously exposed to foreign molecules.

How are immunoglobulins used in the field of medicine

Immunoglobulin levels are useful biomarkers for monitoring many different diseases, including immunodeficiencies and autoimmune diseases.
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Charlotte Lee 25 minutes ago
Your doctor may recommend testing your immunoglobulin levels if immunodeficiency runs in your family...
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Your doctor may recommend testing your immunoglobulin levels if immunodeficiency runs in your family or if you have symptoms of a condition associated with atypical immunoglobulin levels like persistent diarrhea or unexplained weight loss. <h3>Low immunoglobulin levels</h3>
Low immunoglobulin levels suggest that your immune system is not functioning optimally.
Your doctor may recommend testing your immunoglobulin levels if immunodeficiency runs in your family or if you have symptoms of a condition associated with atypical immunoglobulin levels like persistent diarrhea or unexplained weight loss.

Low immunoglobulin levels

Low immunoglobulin levels suggest that your immune system is not functioning optimally.
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Conditions associated with low immunoglobulin levels include:serious infectionsmedication side effectskidney diseaseburnsmalnutrition
Some people are born with lower-than-normal immunoglobulin levels. IgA deficiency occurs in about 1 in 700 people, according to the National Health Service. <h3>High immunoglobulin levels</h3>
Elevated immunoglobulin levels are seen in people with conditions such as:autoimmune diseasehepatitiscirrhosischronic infectionsome cancers like multiple myelomaallergiesinflammatory bowel disease
 <h3>Antibody deficiency disorders</h3>
Some people do not produce immunoglobulins or do not produce as many immunoglobulins as they typically should.
Conditions associated with low immunoglobulin levels include:serious infectionsmedication side effectskidney diseaseburnsmalnutrition Some people are born with lower-than-normal immunoglobulin levels. IgA deficiency occurs in about 1 in 700 people, according to the National Health Service.

High immunoglobulin levels

Elevated immunoglobulin levels are seen in people with conditions such as:autoimmune diseasehepatitiscirrhosischronic infectionsome cancers like multiple myelomaallergiesinflammatory bowel disease

Antibody deficiency disorders

Some people do not produce immunoglobulins or do not produce as many immunoglobulins as they typically should.
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These conditions are called antibody deficiency disorders. They may present shortly after birth with recurrent infections.
These conditions are called antibody deficiency disorders. They may present shortly after birth with recurrent infections.
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Sophia Chen 22 minutes ago
These conditions are often treated with intravenous immune globulin (IVIG) where immunoglobulins are...
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Lucas Martinez 9 minutes ago
This happens through a process called molecular mimicry. In molecular mimicry, the paratopes of circ...
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These conditions are often treated with intravenous immune globulin (IVIG) where immunoglobulins are infused through a vein. Other people have autoimmune conditions where they produce immunoglobulins against their own cells.
These conditions are often treated with intravenous immune globulin (IVIG) where immunoglobulins are infused through a vein. Other people have autoimmune conditions where they produce immunoglobulins against their own cells.
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Audrey Mueller 19 minutes ago
This happens through a process called molecular mimicry. In molecular mimicry, the paratopes of circ...
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This happens through a process called molecular mimicry. In molecular mimicry, the paratopes of circulating immunoglobulins that are primed against an earlier infection closely resemble innocent epitopes on the surface of healthy cells.
This happens through a process called molecular mimicry. In molecular mimicry, the paratopes of circulating immunoglobulins that are primed against an earlier infection closely resemble innocent epitopes on the surface of healthy cells.
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IVIG is often used to treat these conditions, which include:ConditionDescriptionimmune thrombocytopeniaautoimmune destruction of plateletsautoimmune hemolytic anemiaautoimmune destruction of red blood cellsGuillain-Barré syndromeautoimmune destruction of nerves that control breathingchronic inflammatory demyelinating polyneuropathyautoimmune destruction of your nerves’ protective coating
 <h2>What do immunoglobulin blood tests measure </h2>
Doctors often order tests to check circulating levels of IgA, IgG, and IgM to measure your immune function. IgD isn’t routinely tested, and its function isn’t fully understood. Here’s a look at immunoglobulin tests and what a low or high score could indicate.
IVIG is often used to treat these conditions, which include:ConditionDescriptionimmune thrombocytopeniaautoimmune destruction of plateletsautoimmune hemolytic anemiaautoimmune destruction of red blood cellsGuillain-Barré syndromeautoimmune destruction of nerves that control breathingchronic inflammatory demyelinating polyneuropathyautoimmune destruction of your nerves’ protective coating

What do immunoglobulin blood tests measure

Doctors often order tests to check circulating levels of IgA, IgG, and IgM to measure your immune function. IgD isn’t routinely tested, and its function isn’t fully understood. Here’s a look at immunoglobulin tests and what a low or high score could indicate.
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Hannah Kim 27 minutes ago
Reference ranges are based on the 2.5th and 97.5th percentiles. Each laboratory establishes its own ...
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Ava White 51 minutes ago
Higher than normal levels may indicate Graves’ disease

Takeaway

Immunoglobulins are mole...
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Reference ranges are based on the 2.5th and 97.5th percentiles. Each laboratory establishes its own reference range, so these values are estimates.Immunoglobulin testApproximate reference rangesConditions associated with a low scoreConditions associated with a high scoreIgA test0.8 to 3.0g/L• some types of leukemia<br>• kidney damage<br>• intestinal problems<br>• ataxia-telangiectasia, <br>• increased risk of severe reaction after blood transfusion<br>• low or lack of IgA production from birth• monoclonal gammopathy of unknown significanc (MGUS)<br>• multiple myeloma<br>• some autoimmune diseases like rheumatoid arthritis<br>–cirrhosisIgD test0.003 to 0.03g/L• researchers are still trying to understand the significance of low IgD• may rarely suggest multiple myelomaIgE test0.0002 to 0.002g/L• can occur with a rare disease called ataxia-telangiectasia• parasitic infection <br>• allergic reactions<br>• asthma<br>• atopic dermatitis<br>• some cancers <br>• some autoimmune diseases<br>• rarely multiple myelomaIgG test6.0 to 16.0g/L• Waldenstrom’s macroglobulinemia<br>• leukemia<br>• kidney damage <br>• rarely, people are born without IgG immunoglobulin• chronic infections like AIDS<br>• MGUS<br>• multiple myeloma<br>• chronic hepatitis, multiple sclerosisIgM test0.4 to 2.5g/L• multiple myeloma<br>• leukemia• MGUS<br>• Waldenstrom’s macroglobulinemia<br>• early viral hepatitis<br>• mononucleosis<br>• rheumatoid arthritis<br>• kidney damage<br>• parasitic infection<br>• new infectionThyroid-stimulating immunoglobulin (TSI) hormoneUnder 0.54 IU/LTSI is a type of IgG that tells the thyroid to release more thyroid hormones.
Reference ranges are based on the 2.5th and 97.5th percentiles. Each laboratory establishes its own reference range, so these values are estimates.Immunoglobulin testApproximate reference rangesConditions associated with a low scoreConditions associated with a high scoreIgA test0.8 to 3.0g/L• some types of leukemia
• kidney damage
• intestinal problems
• ataxia-telangiectasia,
• increased risk of severe reaction after blood transfusion
• low or lack of IgA production from birth• monoclonal gammopathy of unknown significanc (MGUS)
• multiple myeloma
• some autoimmune diseases like rheumatoid arthritis
–cirrhosisIgD test0.003 to 0.03g/L• researchers are still trying to understand the significance of low IgD• may rarely suggest multiple myelomaIgE test0.0002 to 0.002g/L• can occur with a rare disease called ataxia-telangiectasia• parasitic infection
• allergic reactions
• asthma
• atopic dermatitis
• some cancers
• some autoimmune diseases
• rarely multiple myelomaIgG test6.0 to 16.0g/L• Waldenstrom’s macroglobulinemia
• leukemia
• kidney damage
• rarely, people are born without IgG immunoglobulin• chronic infections like AIDS
• MGUS
• multiple myeloma
• chronic hepatitis, multiple sclerosisIgM test0.4 to 2.5g/L• multiple myeloma
• leukemia• MGUS
• Waldenstrom’s macroglobulinemia
• early viral hepatitis
• mononucleosis
• rheumatoid arthritis
• kidney damage
• parasitic infection
• new infectionThyroid-stimulating immunoglobulin (TSI) hormoneUnder 0.54 IU/LTSI is a type of IgG that tells the thyroid to release more thyroid hormones.
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Higher than normal levels may indicate Graves’ disease
 <h2>Takeaway</h2>
Immunoglobulins are molecules produced by plasma cells following B cell activation due to exposure to a foreign agent. B cells are white blood cells of lymphoid lineage. Many different health conditions are associated with high or low immunoglobulin levels.
Higher than normal levels may indicate Graves’ disease

Takeaway

Immunoglobulins are molecules produced by plasma cells following B cell activation due to exposure to a foreign agent. B cells are white blood cells of lymphoid lineage. Many different health conditions are associated with high or low immunoglobulin levels.
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A doctor may recommend testing your immunoglobulin levels if you have a family history of immunodeficiency or symptoms of a condition associated with atypical immunoglobulin levels. Last medically reviewed on October 14, 2022
 <h3>How we vetted this article </h3>
SourcesHistoryHealthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references.
A doctor may recommend testing your immunoglobulin levels if you have a family history of immunodeficiency or symptoms of a condition associated with atypical immunoglobulin levels. Last medically reviewed on October 14, 2022

How we vetted this article

SourcesHistoryHealthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references.
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You can learn more about how we ensure our content is accurate and current by reading our editorial policy.Anatomy and Physiology (Boundless). (2020).<br/>med.libretexts.org/Bookshelves/Anatomy_and_Physiology/Book%3A_Anatomy_and_Physiology_(Boundless)/00%3A_Front_Matter/02%3A_InfoPageAntibody.
You can learn more about how we ensure our content is accurate and current by reading our editorial policy.Anatomy and Physiology (Boundless). (2020).
med.libretexts.org/Bookshelves/Anatomy_and_Physiology/Book%3A_Anatomy_and_Physiology_(Boundless)/00%3A_Front_Matter/02%3A_InfoPageAntibody.
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Immunoglobulin.<br/>ncbi.nlm.nih.gov/books/NBK513460/Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Current Version
Oct 14, 2022
By
Daniel Yetman
Edited By
Willow Banks
Medically Reviewed By
William C Lloyd III, MD, FACS
Copy Edited By
Delores Smith-Johnson
Share this articleMedically reviewed by William C Lloyd III, MD, FACS — By Daniel Yetman on October 14, 2022
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Antigens and antibodies work together in your immune system.
Immunoglobulin.
ncbi.nlm.nih.gov/books/NBK513460/Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Current Version Oct 14, 2022 By Daniel Yetman Edited By Willow Banks Medically Reviewed By William C Lloyd III, MD, FACS Copy Edited By Delores Smith-Johnson Share this articleMedically reviewed by William C Lloyd III, MD, FACS — By Daniel Yetman on October 14, 2022

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Aria Nguyen 86 minutes ago
Learn more.READ MOREWhat Are Immunomodulators?Medically reviewed by Angelica Balingit, MD Immunomodu...
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Learn more.READ MOREWhat Are Immunomodulators?Medically reviewed by Angelica Balingit, MD
Immunomodulators modulate the immune system to help your body respond to a disease or illness. Learn about the different types, uses, effectiveness…READ MOREYour FAQs Answered: Autoimmune Disorder vs.
Learn more.READ MOREWhat Are Immunomodulators?Medically reviewed by Angelica Balingit, MD Immunomodulators modulate the immune system to help your body respond to a disease or illness. Learn about the different types, uses, effectiveness…READ MOREYour FAQs Answered: Autoimmune Disorder vs.
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Scarlett Brown 53 minutes ago
ImmunocompromisedMedically reviewed by Meredith Goodwin, MD, FAAFP This article explains what autoim...
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ImmunocompromisedMedically reviewed by Meredith Goodwin, MD, FAAFP
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ImmunocompromisedMedically reviewed by Meredith Goodwin, MD, FAAFP This article explains what autoimmune disorders and immunocompromised conditions are and how they're different.READ MOREDiseases of Connective Tissue, from Genetic to AutoimmuneMedically reviewed by Angelica Balingit, MD Diseases of connective tissue include a large number of different disorders that can affect various parts of the body. Here's what you should know.READ MORE*clone Market VIP* The 11 Best Mattresses for Lower Back Pain in 2022Medically reviewed by Gregory Minnis, DPT These 11 picks are some of the best mattresses for lower back pain. Offering medium-firm support, they’ll help keep you aligned and rested.READ MORE
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Evelyn Zhang 41 minutes ago
Immunoglobulins and Immunoglobulin Tests: Function and Clinical Uses Health ConditionsFeaturedBreast...

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