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%Start How to Recognize Signs and Symptoms of Shy Drager Syndrome Health ConditionsFeaturedBreast CancerIBD MigraineMultiple Sclerosis (MS)Rheumatoid ArthritisType 2 DiabetesSponsored TopicsArticlesAcid RefluxADHDAllergiesAlzheimer&#x27;s &amp; DementiaBipolar DisorderCancerCrohn&#x27;s DiseaseChronic PainCold &amp; FluCOPDDepressionFibromyalgiaHeart DiseaseHigh CholesterolHIVHypertensionIPFOsteoarthritisPsoriasisSkin Disorders and CareSTDsDiscoverWellness TopicsNutritionFitnessSkin CareSexual HealthWomen&#x27;s HealthMental HealthSleepOriginal SeriesFresh Food FastDiagnosis DiariesYou’re Not AlonePresent TenseVideo SeriesYouth in FocusHealthy HarvestNo More SilenceFuture of HealthPlanHealth ChallengesMindful EatingSugar SavvyMove Your BodyGut HealthMood FoodsAlign Your SpineFind CarePrimary CareMental HealthOB-GYNDermatologistsNeurologistsCardiologistsOrthopedistsLifestyle QuizzesWeight ManagementAm I Depressed? A Quiz for TeensAre You a Workaholic?How Well Do You Sleep?Tools &amp; ResourcesHealth NewsFind a DietFind Healthy SnacksDrugs A-ZHealth A-ZConnectFind Your Bezzy CommunityBreast CancerInflammatory Bowel DiseasePsoriatic ArthritisMigraineMultiple SclerosisPsoriasisFollow us on social mediaShopProducts by ConditionInsomniaStress ReliefBack PainNeck PainSleep ApneaHot SleepersAllergiesPain ReliefProduct ReviewsVitamins &amp; SupplementsSleepMental HealthNutritionAt-Home TestingCBDMen’s HealthWomen’s HealthHealth ConditionsDiscoverPlanConnectShopSubscribe <h1>Shy Drager Syndrome How to Recognize Signs and Symptoms</h1>Medically reviewed by Angelica Balingit, MD — By Rachael Zimlich, RN, BSN on September 19, 2022Shy Drager syndrome was the name for the condition now known as multiple system atrophy (MSA), a neurological condition first recognized in the 1960s.
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%Start How to Recognize Signs and Symptoms of Shy Drager Syndrome Health ConditionsFeaturedBreast CancerIBD MigraineMultiple Sclerosis (MS)Rheumatoid ArthritisType 2 DiabetesSponsored TopicsArticlesAcid RefluxADHDAllergiesAlzheimer's & DementiaBipolar DisorderCancerCrohn's DiseaseChronic PainCold & FluCOPDDepressionFibromyalgiaHeart DiseaseHigh CholesterolHIVHypertensionIPFOsteoarthritisPsoriasisSkin Disorders and CareSTDsDiscoverWellness TopicsNutritionFitnessSkin CareSexual HealthWomen's HealthMental HealthSleepOriginal SeriesFresh Food FastDiagnosis DiariesYou’re Not AlonePresent TenseVideo SeriesYouth in FocusHealthy HarvestNo More SilenceFuture of HealthPlanHealth ChallengesMindful EatingSugar SavvyMove Your BodyGut HealthMood FoodsAlign Your SpineFind CarePrimary CareMental HealthOB-GYNDermatologistsNeurologistsCardiologistsOrthopedistsLifestyle QuizzesWeight ManagementAm I Depressed? A Quiz for TeensAre You a Workaholic?How Well Do You Sleep?Tools & ResourcesHealth NewsFind a DietFind Healthy SnacksDrugs A-ZHealth A-ZConnectFind Your Bezzy CommunityBreast CancerInflammatory Bowel DiseasePsoriatic ArthritisMigraineMultiple SclerosisPsoriasisFollow us on social mediaShopProducts by ConditionInsomniaStress ReliefBack PainNeck PainSleep ApneaHot SleepersAllergiesPain ReliefProduct ReviewsVitamins & SupplementsSleepMental HealthNutritionAt-Home TestingCBDMen’s HealthWomen’s HealthHealth ConditionsDiscoverPlanConnectShopSubscribe

Shy Drager Syndrome How to Recognize Signs and Symptoms

Medically reviewed by Angelica Balingit, MD — By Rachael Zimlich, RN, BSN on September 19, 2022Shy Drager syndrome was the name for the condition now known as multiple system atrophy (MSA), a neurological condition first recognized in the 1960s.
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Lily Watson 1 minutes ago
It was traditionally diagnosed when someone began to lose control and coordination over a range of b...
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Milton Shy of the National Institutes of Health and Dr. Glen Drager of the Baylor College of Medicin...
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It was traditionally diagnosed when someone began to lose control and coordination over a range of body systems, including: movementblood pressureurinationbreathingswallowing This article will explore what MSA is, why the name was changed, and how to tell this condition apart from so many other neurological diseases. <h2>What is Shy Drager syndrome </h2> MSA is a neurodegenerative condition that causes you to slowly lose control and coordination over a range of body systems. It was first recognized in the 1960s by Dr.
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It was traditionally diagnosed when someone began to lose control and coordination over a range of body systems, including: movementblood pressureurinationbreathingswallowing This article will explore what MSA is, why the name was changed, and how to tell this condition apart from so many other neurological diseases.

What is Shy Drager syndrome

MSA is a neurodegenerative condition that causes you to slowly lose control and coordination over a range of body systems. It was first recognized in the 1960s by Dr.
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Milton Shy of the National Institutes of Health and Dr. Glen Drager of the Baylor College of Medicine.
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Milton Shy of the National Institutes of Health and Dr. Glen Drager of the Baylor College of Medicine.
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Lily Watson 8 minutes ago
Back then, orthostatic hypotension was believed to be the primary problem. As time went on and knowl...
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James Smith 2 minutes ago

Who Gets Shy Drager syndrome

MSA is a rare neurological disease. It often appears in peopl...
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Back then, orthostatic hypotension was believed to be the primary problem. As time went on and knowledge about this syndrome increased, its description and name were updated to better reflect the scope of the disease.
Audrey Mueller Member
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Back then, orthostatic hypotension was believed to be the primary problem. As time went on and knowledge about this syndrome increased, its description and name were updated to better reflect the scope of the disease.
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Lily Watson 8 minutes ago

Who Gets Shy Drager syndrome

MSA is a rare neurological disease. It often appears in peopl...
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Mia Anderson 3 minutes ago
Of the two subgroups of MSA that are now recognized, MSA-C is more commonly found in Japan, whereas ...
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<h3>Who Gets Shy Drager syndrome </h3> MSA is a rare neurological disease. It often appears in people around age 60, and men are twice as likely to develop the condition as women. Overall, there are only about 0.6 to 0.7 new cases of MSA per 100,000 people each year.
Dylan Patel Member
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Who Gets Shy Drager syndrome

MSA is a rare neurological disease. It often appears in people around age 60, and men are twice as likely to develop the condition as women. Overall, there are only about 0.6 to 0.7 new cases of MSA per 100,000 people each year.
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Henry Schmidt 8 minutes ago
Of the two subgroups of MSA that are now recognized, MSA-C is more commonly found in Japan, whereas ...
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Chloe Santos 6 minutes ago
The paper outlined specific diagnostic criteria for the condition and suggested the name change to b...
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Of the two subgroups of MSA that are now recognized, MSA-C is more commonly found in Japan, whereas MSA-P is the variety most often diagnosed in Western countries. <h2>Why is MSA no longer called Shy Drager syndrome </h2>The name Shy Drager Syndrome was changed to MSA in 1998 after a consensus statement was published that clearly defined the broad spectrum of effects the condition could have.
Henry Schmidt Member
access_time 30 minutes ago
Of the two subgroups of MSA that are now recognized, MSA-C is more commonly found in Japan, whereas MSA-P is the variety most often diagnosed in Western countries.

Why is MSA no longer called Shy Drager syndrome

The name Shy Drager Syndrome was changed to MSA in 1998 after a consensus statement was published that clearly defined the broad spectrum of effects the condition could have.
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Grace Liu 8 minutes ago
The paper outlined specific diagnostic criteria for the condition and suggested the name change to b...
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The paper outlined specific diagnostic criteria for the condition and suggested the name change to better reflect the way the disease originates. In addition to the name change, the 1998 paper also categorized the condition into two subgroups.MSA-P: features more parkinsonian symptoms like tremors, rigid muscles, and movement problemsMSA-C: has more cerebellar features, like coordination problems alongside speech or vision difficulties <h2>What are the signs and symptoms of Shy Drager syndrome </h2> As described in the revised name, multiple system atrophy, atrophy is the hallmark symptom of MSA. There’s a wide range of effects when it comes to MSA, based on the severity of the condition and what areas of the body are most impacted.
Scarlett Brown Member
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The paper outlined specific diagnostic criteria for the condition and suggested the name change to better reflect the way the disease originates. In addition to the name change, the 1998 paper also categorized the condition into two subgroups.MSA-P: features more parkinsonian symptoms like tremors, rigid muscles, and movement problemsMSA-C: has more cerebellar features, like coordination problems alongside speech or vision difficulties

What are the signs and symptoms of Shy Drager syndrome

As described in the revised name, multiple system atrophy, atrophy is the hallmark symptom of MSA. There’s a wide range of effects when it comes to MSA, based on the severity of the condition and what areas of the body are most impacted.
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Zoe Mueller 27 minutes ago
About half of the people with this condition become wheelchair-bound due to a progressive lack of mo...
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About half of the people with this condition become wheelchair-bound due to a progressive lack of motor skills within 5 to 6 years of diagnosis. Some of the symptoms reported with MSA include:fatigueweaknessblurred visionproblems with bowel or bladder controlincontinenceerectile dysfunctionconstipationdry skin Eventually, most people with this condition progress to some degree of autonomic dysfunction.
Evelyn Zhang Member
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About half of the people with this condition become wheelchair-bound due to a progressive lack of motor skills within 5 to 6 years of diagnosis. Some of the symptoms reported with MSA include:fatigueweaknessblurred visionproblems with bowel or bladder controlincontinenceerectile dysfunctionconstipationdry skin Eventually, most people with this condition progress to some degree of autonomic dysfunction.
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Thomas Anderson 8 minutes ago
The diagnosis may further be categorized based on unique symptoms, and what body systems are affecte...
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The diagnosis may further be categorized based on unique symptoms, and what body systems are affected. As mentioned above, MSA-P has a similar presentation as Parkinson’s disease, with symptoms like:slowed voluntary movementsmuscle stiffnesspoor balancejerking movements in the hands or fingers About 90% of all people with MSA will experience MSA-P symptoms.
William Brown Member
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The diagnosis may further be categorized based on unique symptoms, and what body systems are affected. As mentioned above, MSA-P has a similar presentation as Parkinson’s disease, with symptoms like:slowed voluntary movementsmuscle stiffnesspoor balancejerking movements in the hands or fingers About 90% of all people with MSA will experience MSA-P symptoms.
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Noah Davis 20 minutes ago
The one symptom that’s common in Parkinson’s disease that’s rarely seen in MSA-P is the “pil...
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Isabella Johnson 30 minutes ago
Specifically, alterations in the alpha-synuclein (SNCA) gene may play a role in the development of M...
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The one symptom that’s common in Parkinson’s disease that’s rarely seen in MSA-P is the “pill-rolling” resting tremor. This is seen in less than 10% of people with MSA-P. Cerebellar symptoms, which impact about 20% of people with MSA, include things like:uncoordinated voluntary movementsprogressive balance lossslurred speechjerkiness to eye movements Other symptoms that can appear in either type of MSA include:exaggerated reflexesincreased muscle tonemuscle spasmscurvature of the spinenoisy or hoarse breathing (stridor)sleep disorderscognitive problems <h2>Is Shy Drager syndrome hereditary </h2> Researchers aren’t really sure what causes MSA, but there appear to be some links in both environmental and genetic factors.
Elijah Patel Member
access_time 30 minutes ago
The one symptom that’s common in Parkinson’s disease that’s rarely seen in MSA-P is the “pill-rolling” resting tremor. This is seen in less than 10% of people with MSA-P. Cerebellar symptoms, which impact about 20% of people with MSA, include things like:uncoordinated voluntary movementsprogressive balance lossslurred speechjerkiness to eye movements Other symptoms that can appear in either type of MSA include:exaggerated reflexesincreased muscle tonemuscle spasmscurvature of the spinenoisy or hoarse breathing (stridor)sleep disorderscognitive problems

Is Shy Drager syndrome hereditary

Researchers aren’t really sure what causes MSA, but there appear to be some links in both environmental and genetic factors.
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Specifically, alterations in the alpha-synuclein (SNCA) gene may play a role in the development of MSA, but more research is needed to fully understand the condition. <h2>How do you diagnose Shy Drager syndrome </h2> If your healthcare professional suspects you have a neurologic disorder like MSA, diagnosis will start with a review of your personal and family medical history, and what symptoms you’re experiencing.
Emma Wilson Admin
access_time 44 minutes ago
Specifically, alterations in the alpha-synuclein (SNCA) gene may play a role in the development of MSA, but more research is needed to fully understand the condition.

How do you diagnose Shy Drager syndrome

If your healthcare professional suspects you have a neurologic disorder like MSA, diagnosis will start with a review of your personal and family medical history, and what symptoms you’re experiencing.
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Some other possible testing methods that might be used include:autonomic testingbladder function testsmagnetic resonance imaging (MRI) of the brainpositron emission tomography (PET) scan of the brain Another test — which is more of a medication challenge — is a trial of levodopa. Levodopa is a medication often used to treat Parkinson’s disease.
David Cohen Member
access_time 48 minutes ago
Some other possible testing methods that might be used include:autonomic testingbladder function testsmagnetic resonance imaging (MRI) of the brainpositron emission tomography (PET) scan of the brain Another test — which is more of a medication challenge — is a trial of levodopa. Levodopa is a medication often used to treat Parkinson’s disease.
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If your doctor prescribes it to you and you have little to no improvement, this is often a sign that...
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This is done by testing the buildup of certain substances and structural changes in your brain tissu...
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If your doctor prescribes it to you and you have little to no improvement, this is often a sign that you have MSA. The only true “gold standard” testing that can be done to confirm an MSA diagnosis, though, is post-mortem testing.
Ryan Garcia Member
access_time 26 minutes ago
If your doctor prescribes it to you and you have little to no improvement, this is often a sign that you have MSA. The only true “gold standard” testing that can be done to confirm an MSA diagnosis, though, is post-mortem testing.
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This is done by testing the buildup of certain substances and structural changes in your brain tissue after you die. <h2>Treatment for Shy Drager syndrome</h2> Currently, there’s no standard treatment for MSA. Most treatments and medications offered for MSA focus on symptoms management and can include things like:ropinirole, pramipexole, or amantadine to control movements or tremorsmidodrine to help increase blood pressureoxybutynin, desmopressin, or catheterization for urinary problemssildenafil, tadalafil, or vardenafil for impotencespeech therapyfeeding support or supplementsrespiratory support with CPAP or tracheostomy <h2>Outlook</h2> The overall outlook for people with MSA is poor, and the condition is often fatal within a decade.
David Cohen Member
access_time 56 minutes ago
This is done by testing the buildup of certain substances and structural changes in your brain tissue after you die.

Treatment for Shy Drager syndrome

Currently, there’s no standard treatment for MSA. Most treatments and medications offered for MSA focus on symptoms management and can include things like:ropinirole, pramipexole, or amantadine to control movements or tremorsmidodrine to help increase blood pressureoxybutynin, desmopressin, or catheterization for urinary problemssildenafil, tadalafil, or vardenafil for impotencespeech therapyfeeding support or supplementsrespiratory support with CPAP or tracheostomy

Outlook

The overall outlook for people with MSA is poor, and the condition is often fatal within a decade.
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How quickly the disease progresses and how severe your symptoms depend in part on how old you were at the time of diagnosis. People who develop symptoms later in life are female, fall a lot, or who have severe autonomic symptoms usually have the highest mortality rates. <h2>Takeaway</h2> While it can be difficult to diagnose MSA and even more difficult to treat it, it’s a disease that usually doesn’t appear until your sixth decade of life or later.
Mason Rodriguez Member
access_time 30 minutes ago
How quickly the disease progresses and how severe your symptoms depend in part on how old you were at the time of diagnosis. People who develop symptoms later in life are female, fall a lot, or who have severe autonomic symptoms usually have the highest mortality rates.

Takeaway

While it can be difficult to diagnose MSA and even more difficult to treat it, it’s a disease that usually doesn’t appear until your sixth decade of life or later.
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Ella Rodriguez 11 minutes ago
Many conditions share the same symptoms as MSA, and an official diagnosis may never be made. Talk wi...
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Many conditions share the same symptoms as MSA, and an official diagnosis may never be made. Talk with your healthcare professional if you’re experiencing problems with movement or balance, or if you often become dizzy when you stand. Last medically reviewed on September 19, 2022 <h3>How we vetted this article </h3> SourcesHistoryHealthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations.
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Many conditions share the same symptoms as MSA, and an official diagnosis may never be made. Talk with your healthcare professional if you’re experiencing problems with movement or balance, or if you often become dizzy when you stand. Last medically reviewed on September 19, 2022

How we vetted this article

SourcesHistoryHealthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations.
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Shy Drager syndrome.
ncbi.nlm.nih.gov/books/NBK560502/Multiple system atrophy/Shy-Drager syndro...
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We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.Fecek C, Nagalli S. (2022).
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We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.Fecek C, Nagalli S. (2022).
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Shy Drager syndrome.
ncbi.nlm.nih.gov/books/NBK560502/Multiple system atrophy/Shy-Drager syndro...
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(n.d.).
vumc.org/autonomic-dysfunction-center/multiple-system-atrophyshy-drager-syndromeMultiple...
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Shy Drager syndrome. <br/>ncbi.nlm.nih.gov/books/NBK560502/Multiple system atrophy/Shy-Drager syndrome.
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Shy Drager syndrome.
ncbi.nlm.nih.gov/books/NBK560502/Multiple system atrophy/Shy-Drager syndrome.
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(n.d.).
vumc.org/autonomic-dysfunction-center/multiple-system-atrophyshy-drager-syndromeMultiple...
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(2019).
multiplesystematrophy.org/about-msa/history-multiple-system-atrophy-formerly-shy-drager-...
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(n.d.).<br/>vumc.org/autonomic-dysfunction-center/multiple-system-atrophyshy-drager-syndromeMultiple system atrophy fact sheet. (2022).<br/>ninds.nih.gov/multiple-system-atrophy-fact-sheetMultiple system atrophy. (n.d.).<br/>rarediseases.org/rare-diseases/multiple-system-atrophy/The history of multiple system atrophy.
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(n.d.).
vumc.org/autonomic-dysfunction-center/multiple-system-atrophyshy-drager-syndromeMultiple system atrophy fact sheet. (2022).
ninds.nih.gov/multiple-system-atrophy-fact-sheetMultiple system atrophy. (n.d.).
rarediseases.org/rare-diseases/multiple-system-atrophy/The history of multiple system atrophy.
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(2019).
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Balance problems can cause dizziness and make it hard to walk without falling. You may feel as thoug...
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(2019).<br/>multiplesystematrophy.org/about-msa/history-multiple-system-atrophy-formerly-shy-drager-syndrome-sds/Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Current Version Sep 19, 2022 By Rachael Zimlich Edited By Mike Hoskins Medically Reviewed By Angelica Balingit, MD Copy Edited By Connor Rice Share this articleMedically reviewed by Angelica Balingit, MD — By Rachael Zimlich, RN, BSN on September 19, 2022 <h3>Read this next</h3>What Causes Poor Balance?Medically reviewed by William Morrison, M.D.
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(2019).
multiplesystematrophy.org/about-msa/history-multiple-system-atrophy-formerly-shy-drager-syndrome-sds/Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Current Version Sep 19, 2022 By Rachael Zimlich Edited By Mike Hoskins Medically Reviewed By Angelica Balingit, MD Copy Edited By Connor Rice Share this articleMedically reviewed by Angelica Balingit, MD — By Rachael Zimlich, RN, BSN on September 19, 2022

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