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% Cell-Derived Therapy May Help Repair Abnormal Heart Rhythm Skip to main content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Menu Close Call 1-800-CEDARS-1 toggle search form Close Los Angeles, 12 April 2022 07:09 AM America/Los_Angeles Cell-Derived Therapy May Help Repair Abnormal Heart Rhythm Ventricular tachycardia, revealed in this printout of a electrocardiogram, is a type of abnormal heart rhythm, or arrhythmia, that occurs when the heart's lower chambers beat too fast. Photo by Getty.
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% Cell-Derived Therapy May Help Repair Abnormal Heart Rhythm Skip to main content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Menu Close Call 1-800-CEDARS-1 toggle search form Close Los Angeles, 12 April 2022 07:09 AM America/Los_Angeles Cell-Derived Therapy May Help Repair Abnormal Heart Rhythm Ventricular tachycardia, revealed in this printout of a electrocardiogram, is a type of abnormal heart rhythm, or arrhythmia, that occurs when the heart's lower chambers beat too fast. Photo by Getty.
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Emergency Cardiology and Intensive Care. Tape ECG with paroxysmal ventricular tachycardia Cedars-Sinai Investigators Found It Also Reduced Scarred Heart Tissue in Animals Vesicles secreted from human heart cells may repair damaged tissue and prevent lethal heart rhythm disorders, according to a new study from investigators in the Smidt Heart Institute at Cedars-Sinai.
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Emergency Cardiology and Intensive Care. Tape ECG with paroxysmal ventricular tachycardia Cedars-Sinai Investigators Found It Also Reduced Scarred Heart Tissue in Animals Vesicles secreted from human heart cells may repair damaged tissue and prevent lethal heart rhythm disorders, according to a new study from investigators in the Smidt Heart Institute at Cedars-Sinai.
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Scarlett Brown 6 minutes ago
The research, published in the European Heart Journal, could lead to a new way to treat a heart rhyt...
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Andrew Wilson 2 minutes ago
Current treatment options for ventricular arrhythmia­s caused by heart attacks are far from ideal. ...
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The research, published in the European Heart Journal, could lead to a new way to treat a heart rhythm problem called ventricular arrhythmia—a top cause of sudden cardiac death. In an accompanying editorial, experts describe the research as “poised to turn this entire field on its head.”  Repairing a Damaged Heart&nbsp Ventricular arrhythmia­s can occur after a heart attack damages tissue, causing chaotic electrical patterns in the heart’s lower chambers. The heart ends up beating so rapidly that it cannot support the circulation, leading to a lack of blood flow and, if untreated, death.
Ryan Garcia Member
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The research, published in the European Heart Journal, could lead to a new way to treat a heart rhythm problem called ventricular arrhythmia—a top cause of sudden cardiac death. In an accompanying editorial, experts describe the research as “poised to turn this entire field on its head.”  Repairing a Damaged Heart&nbsp Ventricular arrhythmia­s can occur after a heart attack damages tissue, causing chaotic electrical patterns in the heart’s lower chambers. The heart ends up beating so rapidly that it cannot support the circulation, leading to a lack of blood flow and, if untreated, death.
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Charlotte Lee 2 minutes ago
Current treatment options for ventricular arrhythmia­s caused by heart attacks are far from ideal. ...
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Liam Wilson 2 minutes ago
Recurrence rates are, unfortunately, high for all of these. “Ablation is a counterintuitive approa...
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Current treatment options for ventricular arrhythmia­s caused by heart attacks are far from ideal. These include medications with major side effects, implanted devices to provide an internal shock, and a procedure called radiofrequency ablation in which parts of the heart are purposely destroyed to interrupt disruptive electrical signals.
Amelia Singh Moderator
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Current treatment options for ventricular arrhythmia­s caused by heart attacks are far from ideal. These include medications with major side effects, implanted devices to provide an internal shock, and a procedure called radiofrequency ablation in which parts of the heart are purposely destroyed to interrupt disruptive electrical signals.
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Evelyn Zhang 3 minutes ago
Recurrence rates are, unfortunately, high for all of these. “Ablation is a counterintuitive approa...
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Alexander Wang 1 minutes ago
“We asked ourselves, ‘What if instead of destroying damaged tissue, we tried to repair it?’”...
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Recurrence rates are, unfortunately, high for all of these. “Ablation is a counterintuitive approach because you are destroying heart muscle in an already weakened heart,” said Eugenio Cingolani, MD, director of the Cardiogenetics-Familial Arrhythmia Program at the Smidt Heart Institute at Cedars-Sinai, and senior author of the study.
Charlotte Lee Member
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Recurrence rates are, unfortunately, high for all of these. “Ablation is a counterintuitive approach because you are destroying heart muscle in an already weakened heart,” said Eugenio Cingolani, MD, director of the Cardiogenetics-Familial Arrhythmia Program at the Smidt Heart Institute at Cedars-Sinai, and senior author of the study.
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“We asked ourselves, ‘What if instead of destroying damaged tissue, we tried to repair it?’” With that in mind, the team sought to try a different approach in laboratory pigs that experienced a heart attack. They injected some of the laboratory pigs with tiny, balloon-like vesicles, called exosomes, produced by cardiosphere-derived cells (CDCs), which are progenitor cells derived from human heart tissue.
Kevin Wang Member
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“We asked ourselves, ‘What if instead of destroying damaged tissue, we tried to repair it?’” With that in mind, the team sought to try a different approach in laboratory pigs that experienced a heart attack. They injected some of the laboratory pigs with tiny, balloon-like vesicles, called exosomes, produced by cardiosphere-derived cells (CDCs), which are progenitor cells derived from human heart tissue.
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James Smith 4 minutes ago
Exosomes are hardy particles containing molecules and the molecular instructions to make various pro...
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Exosomes are hardy particles containing molecules and the molecular instructions to make various proteins, thus they are easier to handle and transfer than the parent cells, or CDCs. CDCs were first developed and characterized by Eduardo Marbán, MD, PhD, executive director of the Smidt Heart Institute at Cedars-Sinai and the Mark S.
Charlotte Lee Member
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Exosomes are hardy particles containing molecules and the molecular instructions to make various proteins, thus they are easier to handle and transfer than the parent cells, or CDCs. CDCs were first developed and characterized by Eduardo Marbán, MD, PhD, executive director of the Smidt Heart Institute at Cedars-Sinai and the Mark S.
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Noah Davis 2 minutes ago
Siegel Family Foundation Distinguished Professor. They have been used in multiple clinical trials fo...
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Alexander Wang 2 minutes ago
Marbán, who is a co-author on the study. The animals were evaluated by MRI and tests to assess elec...
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Siegel Family Foundation Distinguished Professor. They have been used in multiple clinical trials for a variety of diseases, most recently Duchenne muscular dystrophy.  One group of pigs received an injection of CDC-derived exosomes in their hearts and the other a placebo. “The exosomes reduced the amount of scar tissue formed in the injured regions of the heart, normalizing the rhythm without weakening the heart,” said Dr.
Zoe Mueller Member
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Siegel Family Foundation Distinguished Professor. They have been used in multiple clinical trials for a variety of diseases, most recently Duchenne muscular dystrophy.  One group of pigs received an injection of CDC-derived exosomes in their hearts and the other a placebo. “The exosomes reduced the amount of scar tissue formed in the injured regions of the heart, normalizing the rhythm without weakening the heart,” said Dr.
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Audrey Mueller 36 minutes ago
Marbán, who is a co-author on the study. The animals were evaluated by MRI and tests to assess elec...
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Lucas Martinez 6 minutes ago
A Novel Therapy&nbsp In an editorial published in the same issue of the European Heart Journal,...
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Marbán, who is a co-author on the study. The animals were evaluated by MRI and tests to assess electrical stability of the heart. Four to six weeks after injection, the laboratory pigs that had received the exosome therapy showed markedly improved heart rhythms and less scarring in their hearts.
Kevin Wang Member
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Marbán, who is a co-author on the study. The animals were evaluated by MRI and tests to assess electrical stability of the heart. Four to six weeks after injection, the laboratory pigs that had received the exosome therapy showed markedly improved heart rhythms and less scarring in their hearts.
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Victoria Lopez 2 minutes ago
A Novel Therapy&nbsp In an editorial published in the same issue of the European Heart Journal,...
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Ella Rodriguez 1 minutes ago
The authors note the approach used by Cedars-Sinai is novel in how it seeks to repair scarring in th...
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A Novel Therapy&nbsp In an editorial published in the same issue of the European Heart Journal, Marine Cacheux, PhD, and Fadi G. Akar, PhD, both of Yale University, summarize the pros and cons of various experimental gene- and cell-based approaches being studied for cardiac arrhythmias. Cedars-Sinai investigators “appear to have successfully combined the best features of cell and gene therapies to address a major unmet clinical need,” according to Cacheux and Akar.
Mia Anderson Member
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A Novel Therapy&nbsp In an editorial published in the same issue of the European Heart Journal, Marine Cacheux, PhD, and Fadi G. Akar, PhD, both of Yale University, summarize the pros and cons of various experimental gene- and cell-based approaches being studied for cardiac arrhythmias. Cedars-Sinai investigators “appear to have successfully combined the best features of cell and gene therapies to address a major unmet clinical need,” according to Cacheux and Akar.
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Emma Wilson 3 minutes ago
The authors note the approach used by Cedars-Sinai is novel in how it seeks to repair scarring in th...
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The authors note the approach used by Cedars-Sinai is novel in how it seeks to repair scarring in the heart, and describe the study as “a paradigm-shifting body of work.”  The investigators plan additional studies. “More studies are needed to to know if the benefits observed in this study persist over a longer period of time,” said James F.
Noah Davis Member
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The authors note the approach used by Cedars-Sinai is novel in how it seeks to repair scarring in the heart, and describe the study as “a paradigm-shifting body of work.”  The investigators plan additional studies. “More studies are needed to to know if the benefits observed in this study persist over a longer period of time,” said James F.
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Dawkins, DVM, a research scientist at Cedars-Sinai and first author of the study, “however, these ...
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Dawkins, DVM, a research scientist at Cedars-Sinai and first author of the study, “however, these preliminary results suggest the possibility for a nondestructive alternative to treating ventricular arrhythmias.” Funding: This study was funded by the National Institutes of Health under award numbers 1K01HL133510-01A1, R01HL135866 and R01HL14750. Read more on the Cedars-Sinai Blog: Is It a Heart Attack or Panic Attack?
Oliver Taylor Member
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Dawkins, DVM, a research scientist at Cedars-Sinai and first author of the study, “however, these preliminary results suggest the possibility for a nondestructive alternative to treating ventricular arrhythmias.” Funding: This study was funded by the National Institutes of Health under award numbers 1K01HL133510-01A1, R01HL135866 and R01HL14750. Read more on the Cedars-Sinai Blog: Is It a Heart Attack or Panic Attack?
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Related Stories RSS feed - Related Stories (opens in new window) View all headlines - Related Stories 15 Years of Heart October 03, 2022 06:01 AM America/Los_Angeles Pioneering heart care is a tradition at Cedars-Sinai. It’s a tradition that took root in 1924, when Cedars-Sinai became home to the first electrocardiogram machine in Los Angeles. The roots grew stronger in the 1970s, when two Cedars-Sinai … Read more From AFib to Fitness Buff A Heart Transformed September 26, 2022 06:01 AM America/Los_Angeles Claudia Huerta, 43, knows a thing or two about transformations.
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Related Stories RSS feed - Related Stories (opens in new window) View all headlines - Related Stories 15 Years of Heart October 03, 2022 06:01 AM America/Los_Angeles Pioneering heart care is a tradition at Cedars-Sinai. It’s a tradition that took root in 1924, when Cedars-Sinai became home to the first electrocardiogram machine in Los Angeles. The roots grew stronger in the 1970s, when two Cedars-Sinai … Read more From AFib to Fitness Buff A Heart Transformed September 26, 2022 06:01 AM America/Los_Angeles Claudia Huerta, 43, knows a thing or two about transformations.
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After being diagnosed with a serious, though common, heart condition called atrial fibrillation (AFib), the payroll manager and Maywood, California, resident transformed herself from … Read more RESEARCH ALERT The New England Journal of Medicine September 17, 2022 08:00 AM America/Los_Angeles FINDINGSA study published today in the New England Journal of Medicine (NEJM) found that among patients with aortic stenosis undergoing transfemoral TAVR, the use of a debris capturing device called cerebral embolic protection reduced the risk of … Read more Show previous items Show next items Contact the Media Team Email: newsroom@cshs.org Contact Cara Martinez Cara.Martinez@cshs.org Share this release Cell-Derived Therapy May Help Repair Abnormal Heart Rhythm Share on: Twitter Share on: Facebook Share on: LinkedIn Search Our Newsroom Social media Visit our Facebook page (opens in new window) Follow us on Twitter (opens in new window) Visit our Youtube profile (opens in new window) (opens in new window) Latest news 07 Oct 2022 - HealthDay: Black Women Less Likely to Get Laparoscopic Fibroid Surgeries 07 Oct 2022 - Faculty Publications: Sept. 29-Oct.
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After being diagnosed with a serious, though common, heart condition called atrial fibrillation (AFib), the payroll manager and Maywood, California, resident transformed herself from … Read more RESEARCH ALERT The New England Journal of Medicine September 17, 2022 08:00 AM America/Los_Angeles FINDINGSA study published today in the New England Journal of Medicine (NEJM) found that among patients with aortic stenosis undergoing transfemoral TAVR, the use of a debris capturing device called cerebral embolic protection reduced the risk of … Read more Show previous items Show next items Contact the Media Team Email: [email protected] Contact Cara Martinez Cara.Martinez@cshs.org Share this release Cell-Derived Therapy May Help Repair Abnormal Heart Rhythm Share on: Twitter Share on: Facebook Share on: LinkedIn Search Our Newsroom Social media Visit our Facebook page (opens in new window) Follow us on Twitter (opens in new window) Visit our Youtube profile (opens in new window) (opens in new window) Latest news 07 Oct 2022 - HealthDay: Black Women Less Likely to Get Laparoscopic Fibroid Surgeries 07 Oct 2022 - Faculty Publications: Sept. 29-Oct.
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