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%Start Alpha-1 Antitrypsin Deficiency and COPD: The Connection Health ConditionsFeaturedBreast CancerIBD MigraineMultiple Sclerosis (MS)Rheumatoid ArthritisType 2 DiabetesSponsored TopicsArticlesAcid RefluxADHDAllergiesAlzheimer's & DementiaBipolar DisorderCancerCrohn's DiseaseChronic PainCold & FluCOPDDepressionFibromyalgiaHeart DiseaseHigh CholesterolHIVHypertensionIPFOsteoarthritisPsoriasisSkin Disorders and CareSTDsDiscoverWellness TopicsNutritionFitnessSkin CareSexual HealthWomen's HealthMental HealthSleepOriginal SeriesFresh Food FastDiagnosis DiariesYou’re Not AlonePresent TenseVideo SeriesYouth in FocusHealthy HarvestNo More SilenceFuture of HealthPlanHealth ChallengesMindful EatingSugar SavvyMove Your BodyGut HealthMood FoodsAlign Your SpineFind CarePrimary CareMental HealthOB-GYNDermatologistsNeurologistsCardiologistsOrthopedistsLifestyle QuizzesWeight ManagementAm I Depressed? A Quiz for TeensAre You a Workaholic?How Well Do You Sleep?Tools & ResourcesHealth NewsFind a DietFind Healthy SnacksDrugs A-ZHealth A-ZConnectFind Your Bezzy CommunityBreast CancerInflammatory Bowel DiseasePsoriatic ArthritisMigraineMultiple SclerosisPsoriasisFollow us on social mediaShopProducts by ConditionInsomniaStress ReliefBack PainNeck PainSleep ApneaHot SleepersAllergiesPain ReliefProduct ReviewsVitamins & SupplementsSleepMental HealthNutritionAt-Home TestingCBDMen’s HealthWomen’s HealthHealth ConditionsDiscoverPlanConnectShopSubscribe
 <h1>Does Alpha-1 Antitrypsin Deficiency  AATD  Cause COPD </h1>Medically reviewed by Adithya Cattamanchi, M.D., Pulmonology — By Daniel Yetman on October 13, 2022
 <h2>What is alpha-1 antitrypsin deficiency </h2>Chronic obstructive pulmonary disease (COPD) is a group of conditions that cause breathing problems.
%Start Alpha-1 Antitrypsin Deficiency and COPD: The Connection Health ConditionsFeaturedBreast CancerIBD MigraineMultiple Sclerosis (MS)Rheumatoid ArthritisType 2 DiabetesSponsored TopicsArticlesAcid RefluxADHDAllergiesAlzheimer's & DementiaBipolar DisorderCancerCrohn's DiseaseChronic PainCold & FluCOPDDepressionFibromyalgiaHeart DiseaseHigh CholesterolHIVHypertensionIPFOsteoarthritisPsoriasisSkin Disorders and CareSTDsDiscoverWellness TopicsNutritionFitnessSkin CareSexual HealthWomen's HealthMental HealthSleepOriginal SeriesFresh Food FastDiagnosis DiariesYou’re Not AlonePresent TenseVideo SeriesYouth in FocusHealthy HarvestNo More SilenceFuture of HealthPlanHealth ChallengesMindful EatingSugar SavvyMove Your BodyGut HealthMood FoodsAlign Your SpineFind CarePrimary CareMental HealthOB-GYNDermatologistsNeurologistsCardiologistsOrthopedistsLifestyle QuizzesWeight ManagementAm I Depressed? A Quiz for TeensAre You a Workaholic?How Well Do You Sleep?Tools & ResourcesHealth NewsFind a DietFind Healthy SnacksDrugs A-ZHealth A-ZConnectFind Your Bezzy CommunityBreast CancerInflammatory Bowel DiseasePsoriatic ArthritisMigraineMultiple SclerosisPsoriasisFollow us on social mediaShopProducts by ConditionInsomniaStress ReliefBack PainNeck PainSleep ApneaHot SleepersAllergiesPain ReliefProduct ReviewsVitamins & SupplementsSleepMental HealthNutritionAt-Home TestingCBDMen’s HealthWomen’s HealthHealth ConditionsDiscoverPlanConnectShopSubscribe

Does Alpha-1 Antitrypsin Deficiency AATD Cause COPD

Medically reviewed by Adithya Cattamanchi, M.D., Pulmonology — By Daniel Yetman on October 13, 2022

What is alpha-1 antitrypsin deficiency

Chronic obstructive pulmonary disease (COPD) is a group of conditions that cause breathing problems.
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The two main ones are chronic bronchitis and emphysema. The American Lung Association estimates that about 16.4 million people in the United States have COPD. The top risk factor is smoking.
The two main ones are chronic bronchitis and emphysema. The American Lung Association estimates that about 16.4 million people in the United States have COPD. The top risk factor is smoking.
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Madison Singh 2 minutes ago
It’s thought that smoking causes about 90% of COPD cases. The other 10% of cases are thought to be...
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Zoe Mueller 6 minutes ago
Read on to learn more about the connection between AATD and COPD.

What is AATD

AATD is a g...
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It’s thought that smoking causes about 90% of COPD cases. The other 10% of cases are thought to be caused by factors such as:air pollutiongeneticsbreathing in fumes and dust
Researchers have identified alpha-1 antitrypsin deficiency (AATD) as a genetic condition that raises your risk of developing COPD. People with AATD have lungs that are more sensitive to damage from environmental factors such as smoking and pollution.
It’s thought that smoking causes about 90% of COPD cases. The other 10% of cases are thought to be caused by factors such as:air pollutiongeneticsbreathing in fumes and dust Researchers have identified alpha-1 antitrypsin deficiency (AATD) as a genetic condition that raises your risk of developing COPD. People with AATD have lungs that are more sensitive to damage from environmental factors such as smoking and pollution.
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Read on to learn more about the connection between AATD and COPD. <h3>What is AATD </h3>
AATD is a genetic condition inherited from your biological parents that causes your body to produce less alpha-1 antitrypsin protein.
Read on to learn more about the connection between AATD and COPD.

What is AATD

AATD is a genetic condition inherited from your biological parents that causes your body to produce less alpha-1 antitrypsin protein.
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Victoria Lopez 4 minutes ago
It increases your risk of:COPDliver diseasepanniculitis, a group of conditions that cause painful bu...
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It increases your risk of:COPDliver diseasepanniculitis, a group of conditions that cause painful bumps under your skinvasculitis, which is inflammation of your blood vessels
AATD is caused by a mutation of the SERPINA1 gene. You need to receive a mutated gene from both biological parents to develop AATD.
It increases your risk of:COPDliver diseasepanniculitis, a group of conditions that cause painful bumps under your skinvasculitis, which is inflammation of your blood vessels AATD is caused by a mutation of the SERPINA1 gene. You need to receive a mutated gene from both biological parents to develop AATD.
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Isabella Johnson 6 minutes ago
More than 150 mutations of the SERPINA1 gene have been identified. The two most common mutations are...
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Thomas Anderson 19 minutes ago
The S mutation is associated with moderately low alpha-1 antitrypsin protein and the Z mutation is a...
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More than 150 mutations of the SERPINA1 gene have been identified. The two most common mutations are called S and Z mutations.
More than 150 mutations of the SERPINA1 gene have been identified. The two most common mutations are called S and Z mutations.
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Isabella Johnson 29 minutes ago
The S mutation is associated with moderately low alpha-1 antitrypsin protein and the Z mutation is a...
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Ethan Thomas 1 minutes ago
If 16.4 million people in the United States have COPD, roughly 164,000 to 656,000 people have AATD. ...
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The S mutation is associated with moderately low alpha-1 antitrypsin protein and the Z mutation is associated with very low levels. AATD is thought to be present in 1 to 4% of people with COPD.
The S mutation is associated with moderately low alpha-1 antitrypsin protein and the Z mutation is associated with very low levels. AATD is thought to be present in 1 to 4% of people with COPD.
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Christopher Lee 2 minutes ago
If 16.4 million people in the United States have COPD, roughly 164,000 to 656,000 people have AATD. ...
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If 16.4 million people in the United States have COPD, roughly 164,000 to 656,000 people have AATD. <h2>How does alpha-1 antitrypsin deficiency cause COPD </h2>
The primary function of alpha-1 antitrypsin protein is to protect your lungs from inflammation caused by factors such as:tobacco smokeinfectionsother irritants
Research suggests that a type of white blood cell called neutrophils and substances created by neutrophils are key for producing inflammation in the airways of people with COPD.
If 16.4 million people in the United States have COPD, roughly 164,000 to 656,000 people have AATD.

How does alpha-1 antitrypsin deficiency cause COPD

The primary function of alpha-1 antitrypsin protein is to protect your lungs from inflammation caused by factors such as:tobacco smokeinfectionsother irritants Research suggests that a type of white blood cell called neutrophils and substances created by neutrophils are key for producing inflammation in the airways of people with COPD.
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Nathan Chen 24 minutes ago
These white blood cells make up about 70% of the white blood cells circulating through your bloodstr...
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Mia Anderson 23 minutes ago
Chronic activation of neutrophils can result in chronic lung inflammation. Alpha-1 antitrypsin prote...
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These white blood cells make up about 70% of the white blood cells circulating through your bloodstream. Neutrophils leave your bloodstream and migrate to your lungs to neutralize infections and irritants.
These white blood cells make up about 70% of the white blood cells circulating through your bloodstream. Neutrophils leave your bloodstream and migrate to your lungs to neutralize infections and irritants.
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Brandon Kumar 1 minutes ago
Chronic activation of neutrophils can result in chronic lung inflammation. Alpha-1 antitrypsin prote...
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Chronic activation of neutrophils can result in chronic lung inflammation. Alpha-1 antitrypsin protein protects your lungs from an enzyme called neutrophil elastase that’s produced by neutrophils in the presence of inflammation as part of their defense mechanism. A side effect of this enzyme is the breakdown of lung tissue.
Chronic activation of neutrophils can result in chronic lung inflammation. Alpha-1 antitrypsin protein protects your lungs from an enzyme called neutrophil elastase that’s produced by neutrophils in the presence of inflammation as part of their defense mechanism. A side effect of this enzyme is the breakdown of lung tissue.
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Thomas Anderson 2 minutes ago
People with AATD produce little to no alpha-1 antitrypsin, which makes them more vulnerable to lung ...
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Henry Schmidt 1 minutes ago
COPD symptoms in smokers with AATD tend to begin between the ages of 40 and 50. They include:shortne...
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People with AATD produce little to no alpha-1 antitrypsin, which makes them more vulnerable to lung damage. <h2>What are the symptoms of COPD caused by an alpha-1 antitrypsin deficiency </h2>
Symptoms of COPD caused by AATD are the same as COPD without AATD, but they tend to develop earlier in life.
People with AATD produce little to no alpha-1 antitrypsin, which makes them more vulnerable to lung damage.

What are the symptoms of COPD caused by an alpha-1 antitrypsin deficiency

Symptoms of COPD caused by AATD are the same as COPD without AATD, but they tend to develop earlier in life.
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Zoe Mueller 28 minutes ago
COPD symptoms in smokers with AATD tend to begin between the ages of 40 and 50. They include:shortne...
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COPD symptoms in smokers with AATD tend to begin between the ages of 40 and 50. They include:shortness of breathwheezingcoughexcess phlegm productionasthmafatiguechest pain when inhaling
 <h2>How do doctors diagnose COPD caused by an alpha-1 antitrypsin deficiency </h2>
COPD is usually diagnosed with a test called spirometry.
COPD symptoms in smokers with AATD tend to begin between the ages of 40 and 50. They include:shortness of breathwheezingcoughexcess phlegm productionasthmafatiguechest pain when inhaling

How do doctors diagnose COPD caused by an alpha-1 antitrypsin deficiency

COPD is usually diagnosed with a test called spirometry.
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During this test, you breathe into a tube connected to a machine that measures how well your lungs are working. A doctor or healthcare professional may also recommend tests to rule out other conditions.
During this test, you breathe into a tube connected to a machine that measures how well your lungs are working. A doctor or healthcare professional may also recommend tests to rule out other conditions.
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These tests include:chest X-rayCT scanarterial blood gas analysisother blood tests
A doctor can tell if you have AATD with a genetic blood test. The Global Initiative for Chronic Obstructive Lung Disease recommends AATD testing for all people with COPD and people with a close family member with AATD. <h2>What is the treatment for COPD caused by alpha-1 antitrypsin deficiency</h2>
If you have no symptoms, a doctor might recommend regular follow-ups and good general lifestyle habits such as:limiting alcohol consumptionexercising regularlymaintaining a moderate weightreceiving a flu shot every year
If you don’t smoke and your lung function is declining quickly, you may be eligible for alpha-1 antitrypsin protein replacement therapy.
These tests include:chest X-rayCT scanarterial blood gas analysisother blood tests A doctor can tell if you have AATD with a genetic blood test. The Global Initiative for Chronic Obstructive Lung Disease recommends AATD testing for all people with COPD and people with a close family member with AATD.

What is the treatment for COPD caused by alpha-1 antitrypsin deficiency

If you have no symptoms, a doctor might recommend regular follow-ups and good general lifestyle habits such as:limiting alcohol consumptionexercising regularlymaintaining a moderate weightreceiving a flu shot every year If you don’t smoke and your lung function is declining quickly, you may be eligible for alpha-1 antitrypsin protein replacement therapy.
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William Brown 11 minutes ago
This treatment is the only specific therapy for AATD and involves IV infusion of alpha-1 antitrypsin...
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Sophia Chen 13 minutes ago
Very severe cases of COPD are sometimes treated with lung transplants. People with AATD make up abou...
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This treatment is the only specific therapy for AATD and involves IV infusion of alpha-1 antitrypsin protein extracted from human donors. General treatment for COPD symptoms includes:short-acting bronchodilator inhalerslong-acting bronchodilator inhalerssteroid inhalerssteroid tabletsmucolyticsantibiotics for respiratory infections
Learn more about COPD medications.
This treatment is the only specific therapy for AATD and involves IV infusion of alpha-1 antitrypsin protein extracted from human donors. General treatment for COPD symptoms includes:short-acting bronchodilator inhalerslong-acting bronchodilator inhalerssteroid inhalerssteroid tabletsmucolyticsantibiotics for respiratory infections Learn more about COPD medications.
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Very severe cases of COPD are sometimes treated with lung transplants. People with AATD make up about 5% of lung transplants worldwide. <h2>What s the outlook for someone with COPD caused by alpha-1 antitrypsin deficiency </h2>
The outlook for people with AATD varies significantly based on factors such as:the specific gene mutation you havelifestyle habits such as smoking and exerciseexposure to chemicals and irritants
Studies suggest that AATD is linked to a 4 to 38% increased chance of developing asthma.
Very severe cases of COPD are sometimes treated with lung transplants. People with AATD make up about 5% of lung transplants worldwide.

What s the outlook for someone with COPD caused by alpha-1 antitrypsin deficiency

The outlook for people with AATD varies significantly based on factors such as:the specific gene mutation you havelifestyle habits such as smoking and exerciseexposure to chemicals and irritants Studies suggest that AATD is linked to a 4 to 38% increased chance of developing asthma.
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Ryan Garcia 5 minutes ago
Most studies have found no difference in survival rate after lung transplants between people with AA...
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Most studies have found no difference in survival rate after lung transplants between people with AATD and COPD and people with only COPD. The outlook for people with AATD is very poor in those who develop cirrhosis. <h2>Frequently asked questions about emphysema caused by AATD</h2>
Here are some frequently asked questions people have about AATD.
Most studies have found no difference in survival rate after lung transplants between people with AATD and COPD and people with only COPD. The outlook for people with AATD is very poor in those who develop cirrhosis.

Frequently asked questions about emphysema caused by AATD

Here are some frequently asked questions people have about AATD.
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Elijah Patel 3 minutes ago

Can testing confirm an AATD

A doctor can use a blood test to examine your alpha-1 antitryp...
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Natalie Lopez 33 minutes ago

Can you prevent AATD from leading to COPD

Early identification of AATD allows you to take ...
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<h3>Can testing confirm an AATD </h3>
A doctor can use a blood test to examine your alpha-1 antitrypsin levels and diagnose AATD. The Alpha-1 Foundation encourages testing for people at high risk of AATD such as anyone with COPD, unexplained liver disease, or a family member with AATD.

Can testing confirm an AATD

A doctor can use a blood test to examine your alpha-1 antitrypsin levels and diagnose AATD. The Alpha-1 Foundation encourages testing for people at high risk of AATD such as anyone with COPD, unexplained liver disease, or a family member with AATD.
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<h3>Can you prevent AATD from leading to COPD </h3>
Early identification of AATD allows you to take early COPD preventive measures such as quitting smoking. Smoking is a key risk factor in developing COPD. Quitting is often difficult, but a doctor can help create a cessation plan that works for you.

Can you prevent AATD from leading to COPD

Early identification of AATD allows you to take early COPD preventive measures such as quitting smoking. Smoking is a key risk factor in developing COPD. Quitting is often difficult, but a doctor can help create a cessation plan that works for you.
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<h3>Can AATD also cause asthma and other lung conditions </h3>
People with AATD seem to be at an increased risk of developing asthma. AATD has also been linked to bronchiectasis, a condition characterized by damage and widening of the tubes that carry air into your lungs. Panacinar emphysema is the most specific type of COPD associated with AATD.

Can AATD also cause asthma and other lung conditions

People with AATD seem to be at an increased risk of developing asthma. AATD has also been linked to bronchiectasis, a condition characterized by damage and widening of the tubes that carry air into your lungs. Panacinar emphysema is the most specific type of COPD associated with AATD.
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Christopher Lee 28 minutes ago

Takeaway

AATD is a genetic condition that puts you at risk of developing COPD. People with ...
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Sofia Garcia 64 minutes ago
A doctor can test for AATD with a blood test. If you have severe COPD and AATD, a doctor might recom...
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<h2>Takeaway</h2>
AATD is a genetic condition that puts you at risk of developing COPD. People with this condition produce less alpha-1 antitrypsin, a molecule that protects your lungs from damage caused by your immune system as a byproduct of its defense against infections and irritants. You need to receive an atypical SERPINA1 gene from both biological parents to develop AATD.

Takeaway

AATD is a genetic condition that puts you at risk of developing COPD. People with this condition produce less alpha-1 antitrypsin, a molecule that protects your lungs from damage caused by your immune system as a byproduct of its defense against infections and irritants. You need to receive an atypical SERPINA1 gene from both biological parents to develop AATD.
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Madison Singh 6 minutes ago
A doctor can test for AATD with a blood test. If you have severe COPD and AATD, a doctor might recom...
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A doctor can test for AATD with a blood test. If you have severe COPD and AATD, a doctor might recommend alpha-1 antitrypsin replacement therapy.
A doctor can test for AATD with a blood test. If you have severe COPD and AATD, a doctor might recommend alpha-1 antitrypsin replacement therapy.
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Last medically reviewed on October 13, 2022
 <h3>How we vetted this article </h3>
SourcesHistoryHealthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.Abdulkarim A, et al.
Last medically reviewed on October 13, 2022

How we vetted this article

SourcesHistoryHealthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.Abdulkarim A, et al.
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(2020). Alpha-1 antitrypsin deficiency.<br/>ncbi.nlm.nih.gov/books/NBK1519/Who should be tested? (n.d.).<br/>alpha1.org/newly-diagnosed/learning-about-alpha-1/testing-for-alpha-1/Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.
(2020). Alpha-1 antitrypsin deficiency.
ncbi.nlm.nih.gov/books/NBK1519/Who should be tested? (n.d.).
alpha1.org/newly-diagnosed/learning-about-alpha-1/testing-for-alpha-1/Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.
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Share this articleMedically reviewed by Adithya Cattamanchi, M.D., Pulmonology — By Daniel Yetman on October 13, 2022
 <h3>Read this next</h3>What Happens When You Quit Smoking?Medically reviewed by Debra Sullivan, Ph.D., MSN, R.N., CNE, COI
Smoking releases thousands of chemicals into your body. The result is not only damage to your lungs, but also your heart and many other body…READ MORECOPD: Facts, Statistics, and YouMedically reviewed by Debra Sullivan, Ph.D., MSN, R.N., CNE, COI
Chronic obstructive pulmonary disease (COPD) is a group of progressive lung diseases that obstruct airflow.
Current Version Oct 13, 2022 By Daniel Yetman Edited By Roman Gokhman Medically Reviewed By Adithya Cattamanchi, MD Copy Edited By Brennan Doherty Share this articleMedically reviewed by Adithya Cattamanchi, M.D., Pulmonology — By Daniel Yetman on October 13, 2022

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What Happens When You Quit Smoking?Medically reviewed by Debra Sullivan, Ph.D., MSN, R.N., CNE, COI Smoking releases thousands of chemicals into your body. The result is not only damage to your lungs, but also your heart and many other body…READ MORECOPD: Facts, Statistics, and YouMedically reviewed by Debra Sullivan, Ph.D., MSN, R.N., CNE, COI Chronic obstructive pulmonary disease (COPD) is a group of progressive lung diseases that obstruct airflow.
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COPD affects 16 million Americans and…READ MOREVaping and COPD: Is There a Connection?Medically re...
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COPD affects 16 million Americans and…READ MOREVaping and COPD: Is There a Connection?Medically reviewed by Judith Marcin, M.D. The link between inhaling tobacco smoke and COPD is clear. But what about electronic cigarette vapor?
COPD affects 16 million Americans and…READ MOREVaping and COPD: Is There a Connection?Medically reviewed by Judith Marcin, M.D. The link between inhaling tobacco smoke and COPD is clear. But what about electronic cigarette vapor?
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Here&#x27;s what you should know about vaping and…READ MOREWhat You Need to Know About the Zephyr Valve for COPDMedically reviewed by Adithya Cattamanchi, M.D. The Zephyr valve is a relatively new, noninvasive treatment that can help some people with severe COPD.READ MOREAcupuncture for COPD: Can It Be Helpful?Medically reviewed by Kerry Boyle D.Ac., M.S., L.Ac., Dipl.
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Elijah Patel 87 minutes ago
Ac., CYT Some research suggests that acupuncture may be an effective complementary treatment for COP...
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Ac., CYT Some research suggests that acupuncture may be an effective complementary treatment for COPD. Learn more about the COPD symptoms that acupuncture may…READ MORECan You Take Gabapentin If You Have COPD? The FDA has warned about gabapentin use in people with certain lung conditions.
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